Vitamin K antagonists (VKA) are not recommended during pregnancy because warfarin (a first-generation VKA) is associated with a malformation syndrome "the fetal warfarin syndrome" (FWS). VKA are also used for rodent management worldwide. Recently, the Committee for Risk Assessment responsible for the European chemical legislation for advances on the safe use of chemicals had classed 8 anticoagulant used as rodenticides in the reprotoxic category 1A or 1B. This classification emerges from a read-across prediction of toxicity considering the warfarin malformation syndrome. Herein, our study explores the teratogenicity of warfarin at the human therapeutic dose and that of bromadiolone, a second-generation anticoagulant rodenticide. Using a rat model, our study demonstrates that warfarin used at the therapeutic dose is able to induce teratogenicity, while in the same conditions bromadiolone does not induce any teratogenic effect, challenging the classification of all VKA as reprotoxic molecules.

中文翻译：

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维生素K拮抗剂灭鼠剂具有不同的致畸活性。

不建议在怀孕期间使用维生素K拮抗剂（VKA），因为华法林（第一代VKA）与畸形综合症“胎儿华法林综合症”（FWS）有关。VKA还用于全世界的啮齿动物管理。最近，负责欧洲化学品立法安全开发进展的风险评估委员会将8种抗凝剂用作杀鼠剂，属于生殖毒性1A或1B类。考虑到华法林畸形综合症，这种分类来自对毒性的交叉预测。在本文中，我们的研究探索了华法林在人用治疗剂量下的致畸性以及溴代丙隆（第二代抗凝血灭鼠剂）的致畸性。使用老鼠模型