A series of dearomatized isoprenylated acylphloroglucinols derivatives, hyperhenols A–E (1–5), as well as seven known analogues (6–12), were characterized from Hypericum henryi. Their structures were determined by combination of NMR, ECD spectroscopy, and X-ray diffraction analysis. Compounds 1 and 6–8 were tested to exhibit potential antitumor properties, of which 6 and 7 inhibited cell growth through inducing apoptosis and cell cycle arrest. In addition, these compounds could induce autophagy and PINK1/Parkin-mediated mitophagy in cancer cell lines, as well as suppress lung cancer A549 cells metastasis in vitro.

中文翻译：

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脱毒的异戊二酰化酰基间苯三酚衍生物具有潜在的抗腐活性。

一系列脱芳烃isoprenylated acylphloroglucinols衍生物，hyperhenols A-E（1 - 5），以及7个的已知类似物（6 - 12）中，从进行了表征金丝桃果树。它们的结构是通过NMR，ECD光谱和X射线衍射分析的组合来确定的。测试化合物1和6 – 8具有潜在的抗肿瘤特性，其中6和7通过诱导凋亡和细胞周期停滞来抑制细胞生长。此外，这些化合物可以诱导癌细胞系中的自噬和PINK1 / Parkin介导的线粒体吞噬，并在体外抑制肺癌A549细胞的转移。