Congenital anomalies of the kidney and urinary tract (CAKUT) include a broad group of birth defects. Exposure to endocrine disrupting chemicals (EDCs) is suspected to be one of the risk factors for CAKUT, and the use of personal care products (PCPs) is a source of EDC exposure. Therefore, this study aimed to investigate the relationship between CAKUT and the use of PCPs in a large birth cohort study. Data from 86,899 pregnant women included in the Japan Environment and Children's Study (JECS), an ongoing nationwide project, were analyzed. The prevalence of CAKUT in newborns was 0.25 % and almost 90 % of subjects used PCPs during mid-late pregnancy. No association was found between CAKUT and PCP use in a model adjusted for the following covariates: maternal age at delivery. The result was persistent after rigorous sensitivity analyses.

中文翻译：

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妊娠期使用个人护理产品与新生儿出生时泌尿系统异常之间的关联：《日本环境与儿童研究》。

肾脏和泌尿系统的先天性异常（CAKUT）包括大量的先天缺陷。怀疑接触内分泌干扰化学物质（EDC）是CAKUT的危险因素之一，个人护理产品（PCP）的使用是EDC接触的来源。因此，本研究旨在调查大型出生队列研究中CAKUT与PCP使用之间的关系。分析了正在进行的全国性项目“日本环境与儿童研究（JECS）”中的86,899名孕妇的数据。新生儿中CAKUT的患病率为0.25％，近90％的受试者在妊娠中期晚期使用过PCP。在针对以下协变量调整的模型中，未发现CAKUT和PCP使用之间的关联：分娩时的产妇年龄。经过严格的敏感性分析，结果是持久的。