Recent evidence suggest that dysregulation of the tumor suppressor P53, in combination with disharmonious activities of the small GTPase RhoA, may lead to irreversible progression of human disease. The purpose of the present study is to communicate the most recent information regarding the highly interrelated P53/RhoA network. Laborious investigations in the association between both components, may reveal new targets for opposing severe human disease, including the acute respiratory distress syndrome.

中文翻译：

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RhoA法规中的P53。

最近的证据表明，抑癌基因P53的失调，再加上小GTPase RhoA的不和谐活性，可能导致人类疾病的不可逆转的发展。本研究的目的是传达有关高度相关的P53 / RhoA网络的最新信息。对这两个部分之间的关​​联进行的艰苦研究可能会揭示出应对严重人类疾病（包括急性呼吸窘迫综合征）的新目标。