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A Cerberus-Inspired Anti-Infective Multicomponent Gatekeeper Hydrogel against Infections with the Emerging "Superbug" Yeast Candida auris.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-02-27 , DOI: 10.1002/mabi.202000005 Dennis Kubiczek 1 , Carolin Flaig 1 , Heinz Raber 1 , Steffen Dietz 1 , Ann-Kathrin Kissmann 1 , Thomas Heerde 1 , Nicholas Bodenberger 2 , Andreas Wittgens 2 , Melaine González-Garcia 3 , Fan Kang 4 , Octavio L Franco 5, 6 , Ludger Staendker 7 , Anselmo J Otero-González 3 , Paul Walther 8 , Kay E Gottschalk 4 , Tanja Weil 2 , Frank Rosenau 1, 2
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-02-27 , DOI: 10.1002/mabi.202000005 Dennis Kubiczek 1 , Carolin Flaig 1 , Heinz Raber 1 , Steffen Dietz 1 , Ann-Kathrin Kissmann 1 , Thomas Heerde 1 , Nicholas Bodenberger 2 , Andreas Wittgens 2 , Melaine González-Garcia 3 , Fan Kang 4 , Octavio L Franco 5, 6 , Ludger Staendker 7 , Anselmo J Otero-González 3 , Paul Walther 8 , Kay E Gottschalk 4 , Tanja Weil 2 , Frank Rosenau 1, 2
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The pathogenic yeast Candida auris has received increasing attention due to its ability to cause fatal infections, its resistance toward important fungicides, and its ability to persist on surfaces including medical devices in hospitals. To brace health care systems for this considerable risk, alternative therapeutic approaches such as antifungal peptides are urgently needed. In clinical wound care, a significant focus has been directed toward novel surgical (wound) dressings as first defense lines against C. auris. Inspired by Cerberus the Greek mythological “hound of Hades” that prevents the living from entering and the dead from leaving hell, the preparation of a gatekeeper hybrid hydrogel is reported featuring lectin‐mediated high‐affinity immobilization of C. auris cells from a collagen gel as a model substratum in combination with a release of an antifungal peptide drug to kill the trapped cells. The vision is an efficient and safe two‐layer medical composite hydrogel for the treatment of severe wound infections that typically occur in hospitals. Providing this new armament to the repertoire of possibilities for wound care in critical (intensive care) units may open new routes to shield and defend patients from infections and clinical facilities from spreading and invasion of C. auris and probably other fungal pathogens.
中文翻译：
Cerberus启发的抗感染多组分关守水凝胶对抗新兴的“ Superbug”酵母假丝酵母感染。
致病性酵母假丝酵母因其引起致命感染的能力，对重要杀菌剂的抵抗力以及在包括医院医疗器械在内的表面上持久的能力而受到越来越多的关注。为了使医疗保健系统承受这种相当大的风险，迫切需要替代治疗方法，例如抗真菌肽。在临床伤口护理中，重要的焦点已经集中在新颖的外科（伤口）敷料上，作为对抗金黄色葡萄球菌的第一道防线。受希腊神话中的“冥想之犬”塞伯鲁斯的启发，它阻止了生命的进入，死者无法离开地狱，据报道，制备了一种由凝集素介导的高亲和力固定化金黄色葡萄球菌的网守混合水凝胶。胶原凝胶中的细胞作为模型基质，结合释放的抗真菌肽药物杀死被捕获的细胞。视觉是一种有效且安全的两层医用复合水凝胶，用于治疗通常在医院中发生的严重伤口感染。在紧急（重症监护）病房中，为伤口护理的可能性提供新的武器可能会开辟新的途径，以保护和保护患者免受感染，并保护临床设施免受金黄色葡萄球菌和其他真菌病原体的扩散和侵袭。
更新日期：2020-02-27
中文翻译：
Cerberus启发的抗感染多组分关守水凝胶对抗新兴的“ Superbug”酵母假丝酵母感染。
致病性酵母假丝酵母因其引起致命感染的能力，对重要杀菌剂的抵抗力以及在包括医院医疗器械在内的表面上持久的能力而受到越来越多的关注。为了使医疗保健系统承受这种相当大的风险，迫切需要替代治疗方法，例如抗真菌肽。在临床伤口护理中，重要的焦点已经集中在新颖的外科（伤口）敷料上，作为对抗金黄色葡萄球菌的第一道防线。受希腊神话中的“冥想之犬”塞伯鲁斯的启发，它阻止了生命的进入，死者无法离开地狱，据报道，制备了一种由凝集素介导的高亲和力固定化金黄色葡萄球菌的网守混合水凝胶。胶原凝胶中的细胞作为模型基质，结合释放的抗真菌肽药物杀死被捕获的细胞。视觉是一种有效且安全的两层医用复合水凝胶，用于治疗通常在医院中发生的严重伤口感染。在紧急（重症监护）病房中，为伤口护理的可能性提供新的武器可能会开辟新的途径，以保护和保护患者免受感染，并保护临床设施免受金黄色葡萄球菌和其他真菌病原体的扩散和侵袭。
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