Dopamine, noradrenaline and adrenaline are catecholamines, and are all produced along the same metabolic pathway. Their discovery dates back to the early 1900s, and they were appreciated until the second half of the century mainly for their role in the brain and in the regulation of autonomic functions. Nonetheless, in the 1970s characterization of the key role of sympathoadrenergic nerve fibers in the cross-talk between the brain and the immune system paved the way to the raise of modern neuroimmunology, and understanding the immune effects of dopamine occurred in the subsequent decades. Both adrenergic and dopaminergic transmission offer a possibly unparalleled wealth of therapeutic targets, and most of them have been already successfully exploited for cardiovascular, respiratory, neurologic and even psychiatric diseases, however so far the therapeutic potential of adrenergic and dopaminergic agents in the neuroimmune network remains relatively unexploited. This special issue provides a unique collection of expert contributions from some of the most prominent researchers currently studying dopaminergic and adrenergic agents in major diseases like cancer, autoimmunity, neurodegeneration, and even in emerging areas like hematology and metabolism. It is strongly hoped that these reviews will be not only helpful for researchers already working on topics related to the neuroimmune pharmacology of catecholamines, but will also attract novel researchers as much work is still needed to fully exploit the therapeutic potential of dopaminergic and adrenergic drugs for the benefit of patients.

中文翻译：

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多巴胺能和肾上腺素途径作为神经免疫网络中药物再利用的目标。

多巴胺，去甲肾上腺素和肾上腺素是儿茶酚胺，并且都沿着相同的代谢途径产生。他们的发现可以追溯到1900年代初，直到二十世纪下半叶才受到人们的赞赏，主要是因为它们在大脑中和在调节自主功能方面发挥了作用。然而，在1970年代，交感神经能神经纤维在大脑与免疫系统之间的串扰中的关键作用表征为现代神经免疫学的发展铺平了道路，并在随后的几十年中了解了多巴胺的免疫作用。肾上腺素能传递和多巴胺能传递都可能提供无与伦比的治疗靶标，并且其中大多数已经被成功用于心血管，呼吸系统，神经系统甚至精神疾病的治疗，然而，到目前为止，在神经免疫网络中肾上腺素能和多巴胺能药物的治疗潜力仍然相对不足。本期特刊汇集了一些最杰出的研究人员的独特研究成果，这些研究人员目前正在研究多巴胺能和肾上腺素能药物，以治疗癌症，自身免疫性疾病，神经退行性疾病甚至血液学和新陈代谢等新兴领域的主要疾病。强烈希望这些评论不仅对已经研究儿茶酚胺神经免疫药理学相关主题的研究人员有所帮助，而且还将吸引新的研究人员，因为仍需要大量工作来充分利用多巴胺能和肾上腺素能药物的治疗潜力。患者的利益。