PURPOSE Cancer and its treatment can affect quality of life (QOL) in cancer patient and family caregiver dyads. However, the factors influencing dyad QOL remain inconclusive. Our study was designed to (i) assess dyads' QOL, and examine the relationship between the QOL of cancer patients and that of their family caregivers, and (ii) investigate factors that may modify this relationship. METHODS Participants comprised 641 cancer patient-family caregiver dyads. Four types of variables were collected as potential influencing factors, including cancer patient-related variables, family caregiver-related variables, family-related variables, and symptom distress-related variables. RESULTS Generally, family caregivers reported better QOL than cancer patients did. The effect sizes of the correlation (r) between cancer patients' QOL and those of their family caregivers ranged from 0.08 to 0.27. Various variables influencing the QOL correlations between cancer patients and family caregivers were identified, including cancer patient-related variables (e.g., age, gender, marital status, understanding of the disease, cancer type and treatment); family caregiver-related variables (e.g., being the spouse or offspring of a patient, duration in their role as a family caregiver, understanding of the disease, and amount of time spent on caregiving each day); family-related variables (e.g., cancer patient enjoyed a good relationship with family pre-cancer diagnosis, family was experiencing serious or mild financial burden due to cancer treatment); and symptom stress-related variables (anxiety and depression). CONCLUSIONS Study findings draw attention to QOL and its related factors in cancer patient-family caregiver dyads. This will benefit the development of interventions to improve dyad QOL.

中文翻译：

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晚期癌症患者及其家庭照顾者生活质量的相互影响和调节因素。


目的 癌症及其治疗会影响癌症患者和家庭护理人员的生活质量 (QOL)。然而，影响二人生活质量的因素仍然没有定论。我们的研究旨在（i）评估夫妻的生活质量，并检查癌症患者的生活质量与其家庭护理人员的生活质量之间的关系，以及（ii）调查可能改变这种关系的因素。方法 参与者由 641 名癌症患者和家庭护理人员组成。收集四类变量作为潜在影响因素，包括癌症患者相关变量、家庭照顾者相关变量、家庭相关变量和症状困扰相关变量。结果 一般来说，家庭护理人员的生活质量比癌症患者的生活质量要好。癌症患者的生活质量与其家庭护理人员的生活质量之间的相关性 (r) 的效应大小范围为 0.08 至 0.27。确定了影响癌症患者和家庭护理人员之间生活质量相关性的各种变量，包括癌症患者相关变量（例如年龄、性别、婚姻状况、对疾病的了解、癌症类型和治疗）；家庭照顾者相关变量（例如，是否为患者的配偶或后代、其作为家庭照顾者角色的持续时间、对疾病的了解以及每天花在照顾上的时间）；家庭相关变量（例如，癌症患者与家庭癌前诊断关系良好、家庭因癌症治疗而承受严重或轻微的经济负担）；以及与症状压力相关的变量（焦虑和抑郁）。结论 研究结果引起人们对癌症患者-家庭护理人员二人组中生活质量及其相关因素的关注。这将有利于改善二人生活质量的干预措施的发展。