Abstract

The PDGF receptor is mock-coupled with a known active compound, and 14 novel skeleton candidate compounds were designed and synthesized. The structure was confirmed by ¹H NMR, ¹³C NMR and MS. The in vitro cytotoxicity of the two cancer cell lines (SGC-7901 and A549) was evaluated by MTT assay. PDGF receptor protein inhibition assays were performed on I₆ and II₄ using fluorescence polarization immunoassay (FPIA).

中文翻译：

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靶向PDGF受体抑制剂的齐墩果酸类似物的合成及其抗肿瘤生物学活性

摘要

PDGF受体与已知的活性化合物进行模拟偶联，设计并合成了14种新型骨架候选化合物。通过¹ H NMR，¹³ C NMR和MS确认结构。在体外两种癌细胞系（SGC-7901和A549）的细胞毒性，通过MTT测定评价。使用荧光偏振免疫测定法（FPIA）在I ₆和II ₄上进行PDGF受体蛋白抑制测定。