Over the last 2 decades, advances in the diagnosis and management of pituitary diseases have made it possible to attain an endocrine "cure" in a large proportion of patients. In other words, tumors can be excised or controlled with drugs, mass effects of the lesion on surrounding structures can be solved, and pituitary deficiencies can be substituted with all relevant hormones. While this is considered a satisfactory outcome for health care providers, patients often suffer from an aftermath of prior endocrine dysfunction exposure, with irreversible effects, both physically and psychologically, which have a great impact on their everyday life. Diagnostic delay, often of several years, adds a negative impact on health perception. This affects their social, professional, and family domains and determines their future life. Understanding that this may occur is important, and health care providers should offer information to prepare the patient for this difficult journey, especially in the case of acromegaly, Cushing disease, or hypopituitarism. In order to maintain a good quality of life (QoL) in the long-term, patients need to adapt to this new situation, something that may be difficult, since they often cannot continue with all the activities and rhythm they used to do. Depression is often the consequence of maladaptation to the new situation, leading to impaired QoL.

中文翻译：

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以患者为中心的垂体和鞍旁疾病的结果。

在过去的 20 年里，垂体疾病的诊断和管理的进步使得大部分患者的内分泌“治愈”成为可能。换句话说，肿瘤可以被切除或用药物控制，可以解决病变对周围结构的占位效应，并且可以用所有相关的激素替代垂体缺陷。虽然这对于医疗保健提供者来说被认为是一个令人满意的结果，但患者经常遭受先前内分泌功能障碍暴露的后果，在身体和心理上产生不可逆转的影响，对他们的日常生活产生重大影响。诊断延迟，通常为数年，对健康认知增加了负面影响。这会影响他们的社交、职业和家庭领域，并决定他们未来的生活。了解这可能发生很重要，医疗保健提供者应提供信息，让患者为这段艰难的旅程做好准备，尤其是在肢端肥大症、库欣病或垂体功能减退症的情况下。为了长期保持良好的生活质量 (QoL)，患者需要适应这种新情况，这可能很困难，因为他们通常无法继续以前的所有活动和节奏。抑郁症通常是对新情况适应不良的结果，导致生活质量下降。患者需要适应这种新情况，这可能很困难，因为他们通常无法继续以前的所有活动和节奏。抑郁症通常是对新情况适应不良的结果，导致生活质量下降。患者需要适应这种新情况，这可能很困难，因为他们通常无法继续以前的所有活动和节奏。抑郁症通常是对新情况适应不良的结果，导致生活质量下降。