The biocompatibility and neuron regenerating properties of various bioactive glass (BG)/polyhydroxyalkanoate (PHA) blend composites were assessed in order to study their suitability for peripheral nerve tissue applications, specifically as lumen structures for nerve guidance conduits. BG/PHA blend composites were fabricated using Bioactive glass® 45 S5 (BG1) and BG 1393 (BG2) with the 25:75 poly(3-hydroxyoctanoate/poly3-hydroxybutyrate), 25:75 P(3HO)/P(3HB) blend (PHA blend). Various concentrations of each BG (0.5 wt%, 1.0 wt% and 2.5 wt%) were used to determine the effect of BG on neuronal growth and differentiation, in single culture using NG108-15 neuronal cells and in a co-culture along with RN22 Schwann cells. NG108-15 cells exhibited good growth and differentiation on all the PHA blend composites showing that both BGs have good biocompatibility at 0.5 wt%, 1.0 wt% and 2.5 wt% within the PHA blend. The Young’s modulus values displayed by all the PHA blend/BG composites rang...

中文翻译：

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基于聚羟基链烷酸酯和生物活性玻璃的复合支架对神经元细胞亲和力的调节。

评估了各种生物活性玻璃 (BG)/聚羟基链烷酸酯 (PHA) 共混复合材料的生物相容性和神经元再生特性，以研究它们对周围神经组织应用的适用性，特别是作为神经导管的管腔结构。BG/PHA 共混复合材料使用 Bioactive glass® 45 S5 (BG1) 和 BG 1393 (BG2) 与 25:75 聚（3-羟基辛酸酯/聚 3-羟基丁酸酯）、25:75 P(3H2O)/P(3HB) 制造混合（PHA 混合）。在使用 NG108-15 神经元细胞的单一培养和与 RN22 的共培养中，使用各种浓度的每种 BG（0.5 wt%、1.0 wt% 和 2.5 wt%）来确定 BG 对神经元生长和分化的影响施万细胞。NG108-15 细胞在所有 PHA 共混复合材料上表现出良好的生长和分化，表明在 PHA 共混物中的 0.5 wt%、1.0 wt% 和 2.5 wt% 时，两种 BG 都具有良好的生物相容性。所有 PHA 共混物/BG 复合材料显示的杨氏模量值范围...