Astrocytomas are primary malignant brain tumors that originate from astrocytes. Grade IV astrocytoma or glioblastoma is a highly invasive tumor that occur within the brain parenchyma. The Rho family of small GTPases, which includes Rac1, Cdc42, and RhoA, is an important family whose members are key regulators of the invasion and migration of glioblastoma cells. In this review, we describe the role played by the Rho family of GTPases in the regulation of the invasion and migration of glioblastoma cells. Specifically, we focus on the role played by RhoA, Rac1, RhoG, and Cdc42 in cell migration through rearrangement of actin cytoskeleton, cell adhesion, and invasion. Finally, we highlight the importance of potentially targeting Rho GTPases in the treatment of glioblastoma.

中文翻译：

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Rho GTPases在胶质母细胞瘤细胞运动和侵袭中的作用。

星形细胞瘤是起源于星形胶质细胞的原发性恶性脑肿瘤。IV级星形细胞瘤或胶质母细胞瘤是发生在脑实质内的高度侵袭性肿瘤。小型RTPase的Rho家族包括Rac1，Cdc42和RhoA，是一个重要的家族，其成员是胶质母细胞瘤细胞侵袭和迁移的关键调节因子。在这篇综述中，我们描述了GTPases Rho家族在胶质母细胞瘤细胞侵袭和迁移调控中所起的作用。具体来说，我们专注于RhoA，Rac1，RhoG和Cdc42在肌动蛋白细胞骨架的重排，细胞粘附和侵袭中在细胞迁移中所起的作用。最后，我们强调了潜在靶向Rho GTPases在胶质母细胞瘤治疗中的重要性。