Background. sST2 represents a useful biomarker for the diagnosis and prognosis of patients with heart failure, but limited data is available on its role in patients with hypertension. The aim of this study is to evaluate the short-term prognosis value of sST2 for an unfavorable outcome in hypertensive patients. Methods. This was a prospective observational study which enrolled 80 patients with hypertension, who were followed for one year. All patients underwent clinical, laboratory (including sST2), and echocardiographic assessment at baseline. The patients were grouped according to the cardiovascular (CV) events reported during the follow-up: group A (with CV events) and group B (without CV events). Results. Overall, 59 CV events were reported during the follow-up period. Compared to group B, the patients in group A had significantly higher sST2 levels, a higher number of CV risk factors, and a higher left ventricle mass. Except for the diastolic dysfunction parameters, the echocardiographic findings were similar in the two groups. Patients in group A had a lower ratio, larger deceleration time, and increased telediastolic pressure as quantified by the ratio than those in group B. Multivariate logistic regression analysis showed that sST2 and fasting plasma glucose at baseline were independent predictors for the CV events reported during the follow-up period. were associated with poor clinical outcomes (, Kaplan-Meier analysis). Conclusions. sST2 levels were correlated with the risk of adverse CV outcomes in hypertensive patients and may represent a useful prognostic marker in these patients.

中文翻译：

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sST2 对高血压患者预后不良的短期预后价值。

背景。sST2 是心力衰竭患者诊断和预后的有用生物标志物，但关于其在高血压患者中的作用的数据有限。本研究的目的是评估 sST2 对高血压患者不利结果的短期预后价值。方法。这是一项前瞻性观察研究，纳入了 80 名高血压患者，随访一年。所有患者在基线时都接受了临床、实验室（包括 sST2）和超声心动图评估。根据随访期间报告的心血管（CV）事件对患者进行分组：A组（有CV事件）和B组（无CV事件）。结果. 总体而言，在随访期间报告了 59 起 CV 事件。与 B 组相比，A 组患者的 sST2 水平显着升高，CV 危险因素数量较多，左心室肿块较多。除舒张功能障碍参数外，两组的超声心动图结果相似。A组患者的比率、更大的减速时间和增加的远程舒张压，由多变量逻辑回归分析显示，基线时的 sST2 和空腹血糖是随访期间报告的 CV 事件的独立预测因子。与不良临床结果相关（, Kaplan-Meier 分析)。结论。sST2 水平与高血压患者不良心血管结局的风险相关，可能代表这些患者的有用预后标志物。