Two neurons can only form a synapse if their axonal and dendritic projections meet at the same time and place. While spatiotemporal proximity is necessary for synapse formation, it remains unclear to what extent the underlying positional strategies are sufficient to ensure synapse formation between the right partners. Many neurons readily form synapses with wrong partners if they find themselves at the wrong place or time. Minimally, restricting spatiotemporal proximity can prevent incorrect synapses. Maximally, restricting encounters in time and space could be sufficient to ensure correct partnerships between neurons that can form synapses promiscuously. In this review we explore recent findings on positional strategies during developmental growth that contribute to precise outcomes in brain wiring.

中文翻译：

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在大脑接线过程中遇到合适伙伴的神经元策略。

两个神经元只有在它们的轴突和树突突起在同一时间和地点相遇时才能形成突触。虽然时空接近对于突触的形成是必要的，但潜在的位置策略在多大程度上足以确保正确伙伴之间的突触形成仍不清楚。如果发现自己在错误的地点或时间，许多神经元很容易与错误的伙伴形成突触。至少，限制时空接近度可以防止不正确的突触。最大限度地，限制时间和空间的相遇可能足以确保可以混杂形成突触的神经元之间的正确伙伴关系。在这篇综述中，我们探讨了有关发育成长过程中位置策略的最新发现，这些发现有助于大脑布线的精确结果。