Abstract

The aim of this narrative review is to summarize the present knowledge on long-term outcome of children born after assisted reproductive technologies (ART). The main outcomes covered are neurodevelopment including cerebral palsy, cognitive development, attention deficit hyperactivity disorder and autism spectrum disease, growth, cardiovascular function, diabetes type 1, asthma, malignancies, and reproductive health. Results have mainly been obtained from systematic reviews/meta-analyses and large registry studies. It has been shown that children born after ART, when restricted to singletons, have a similar outcome for many health conditions as their spontaneously conceived peers. For some outcomes, particularly cardiovascular function and diabetes, studies show some higher risk for ART singletons or subgroup of ART singletons. The fast introduction of new ART techniques emphasizes the importance of continuous surveillance of children born after ART.

摘要

这篇叙述性综述的目的是总结有关辅助生殖技术（ART）后出生的儿童的长期结局的现有知识。涵盖的主要结果是神经发育，包括脑瘫，认知发育，注意缺陷多动障碍和自闭症谱系疾病，生长，心血管功能，1型糖尿病，哮喘，恶性肿瘤和生殖健康。结果主要来自系统评价/元分析和大型注册研究。研究表明，在接受ART治疗后出生的孩子，如果被限制为单胎，在许多健康状况上的后果与自发的同龄人相似。对于某些结局，特别是心血管功能和糖尿病，研究显示ART单身人士或ART单身人士亚组的较高风险。