Handedness is an elusive human behavioral phenotypes and the genetic basis of it remains unclear until now. The aim of this study is to evaluate the genetic correlations between left-handedness and multiple mental disorders, and explored the genes detected by genetic correlations. In this study, linkage disequilibrium score regression (LDSC) analysis was conducted to evaluate the genetic correlations between left-handedness and multiple mental disorders. The significant genetic correlation was only observed between left-handedness and schizophrenia (SCZ). For the observed genetic correlation, transcriptome-wide association study (TWAS) was performed to identify the genes associated with left-handedness and SCZ, including brain RNA-seq (CBR) and brain RNA-seq splicing (CBRS). We detected several common genes associated with both left-handedness and SCZ, such as YWHAH, MAPT and ANO10. The common genes shared by left-handedness and SCZ were subjected to gene set enrichment analysis. Our study provides a novel clue for understanding the genetic correlation between left-handedness and SCZ.

中文翻译：

---

使用连锁不平衡得分回归和转录组全关联研究评估左撇子与精神障碍之间的遗传相关性。

惯性是人类难以捉摸的行为表型，其遗传基础至今仍不清楚。这项研究的目的是评估左撇子和多种精神障碍之间的遗传相关性，并探索通过遗传相关性检测到的基因。在这项研究中，进行了连锁不平衡得分回归（LDSC）分析，以评估左撇子和多种精神障碍之间的遗传相关性。仅在惯用左手和精神分裂症（SCZ）之间观察到显着的遗传相关性。对于观察到的遗传相关性，进行了转录组范围关联研究（TWAS），以鉴定与惯用左手和SCZ相关的基因，包括脑RNA-seq（CBR）和脑RNA-seq剪接（CBRS）。我们检测到了一些与左撇子和SCZ相关的常见基因，例如YWHAH，MAPT和ANO10。对左撇子和SCZ共有的常见基因进行了基因集富集分析。我们的研究为理解左撇子和SCZ之间的遗传相关性提供了一条新的线索。