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Immunoglobulin E-Mediated Food Allergies Differ in East Mediterranean Children Aged 0-2 Years.
International Archives of Allergy and Immunology ( IF 2.5 ) Pub Date : 2020-02-25 , DOI: 10.1159/000505996
Melike Kahveci 1 , Gizem Koken 2 , Ümit Murat Şahiner 1 , Özge Soyer 1 , Bülent Enis Şekerel 3
Affiliation  

OBJECTIVE Precise diagnosis of allergy requires knowledge of the population's food allergy (FA) spectrum and predictors. METHODS Medical charts of Turkish children aged 0-2 years with FA and/or atopic dermatitis (AD) were reviewed. RESULTS A total of 1,389 patients, 912 with FA and 1,140 with AD, were included. In the FA group, the most frequently diagnosed FAs were egg white (75.9%), cow's milk (55.7%), tree nuts (31.5%) and sesame (20.6%). The detection of FA in 99% of children with any kind of FA necessitate testing with egg white, cow's milk, hazelnut, sesame, walnut, cashew, and pistachio. In the FA group, 72.7 and 56.8% had AD and multiple FA respectively. Multiple FA (56.8 vs. 49.8%) and hen's egg allergy (85.5 vs. 50.2%, p < 0.005) were more common and cow's milk allergy (51.4 vs. 67.1%, p < 0.005) less common in the AD subgroup of the FA group than in the non-AD subgroup. Multiple FA likelihood increases parallel to the severity of AD (p < 0.05). In the AD group, 58.2% had an immunoglobulin E-mediated FA. The risk of concomitant FA increased as the age at symptom onset of AD decreased (OR 0.800 [95% CI 0.731-0.875]; p < 0.001) and the severity of AD increased (OR 2.350 [95% CI 1.898-2.911]; p < 0.001). CONCLUSION Although severe and early-onset AD is a predictor of the presence and magnitude of FA in infancy, the spectrum of FA is a reflection of cultural characteristics. The clinical presentations of both AD and FA may in fact be an expression of the extent of the immune dysregulation underlying atopy and allergy.

中文翻译:

东地中海0至2岁儿童的免疫球蛋白电子介导的食物过敏情况有所不同。

目的过敏的精确诊断需要了解人群的食物过敏(FA)谱和预测因子。方法回顾了土耳其0至2岁患有FA和/或特应性皮炎(AD)的儿童的病历。结果共纳入1389例患者,其中912例为FA,1140例为AD。在FA组中,最常被诊断的FA是蛋清(75.9%),牛奶(55.7%),坚果(31.5%)和芝麻(20.6%)。对99%患有FA的儿童进行FA检测需要对蛋清,牛奶,榛子,芝麻,核桃,腰果和开心果进行检测。在FA组中,分别有AD和多重FA的分别为72.7和56.8%。多种FA(56.8 vs. 49.8%)和鸡蛋过敏(85.5 vs. 50.2%,p <0.005)更常见,而牛奶过敏(51.4 vs. 67.1%,p <0)。005)在FA组的AD子组中比在非AD子组中少见。多个FA可能性与AD的严重程度平行增加(p <0.05)。在AD组中,有58.2%的人具有免疫球蛋白E介导的FA。随着AD发病年龄的降低,伴随FA的风险增加(OR 0.800 [95%CI 0.731-0.875]; p <0.001)和AD严重程度增加(OR 2.350 [95%CI 1.898-2.911]; p <0.001)。结论尽管严重和早发性AD可以预测婴儿期FA的存在和程度,但FA的频谱反映了其文化特征。AD和FA的临床表现实际上可能是特应性和变态反应背后的免疫失调程度的一种表达。多个FA可能性与AD的严重程度平行增加(p <0.05)。在AD组中,有58.2%的人具有免疫球蛋白E介导的FA。随着AD发病年龄的降低,伴随FA的风险增加(OR 0.800 [95%CI 0.731-0.875]; p <0.001)和AD严重程度增加(OR 2.350 [95%CI 1.898-2.911]; p <0.001)。结论尽管严重和早发性AD可以预测婴儿期FA的存在和程度,但FA的频谱反映了其文化特征。AD和FA的临床表现实际上可能是特应性和变态反应背后的免疫失调程度的一种表达。多个FA可能性与AD的严重程度平行增加(p <0.05)。在AD组中,有58.2%的人具有免疫球蛋白E介导的FA。随着AD发病年龄的降低,伴随FA的风险增加(OR 0.800 [95%CI 0.731-0.875]; p <0.001)和AD严重程度增加(OR 2.350 [95%CI 1.898-2.911]; p <0.001)。结论尽管严重和早发性AD可以预测婴儿期FA的存在和程度,但FA的频谱反映了其文化特征。AD和FA的临床表现实际上可能是特应性和变态反应基础的免疫失调程度的一种表达。875];p <0.001)和AD严重程度增加(OR 2.350 [95%CI 1.898-2.911]; p <0.001)。结论尽管严重和早发性AD可以预测婴儿期FA的存在和程度,但FA的频谱反映了其文化特征。AD和FA的临床表现实际上可能是特应性和变态反应基础的免疫失调程度的一种表达。875];p <0.001)和AD严重程度增加(OR 2.350 [95%CI 1.898-2.911]; p <0.001)。结论尽管严重和早发性AD可以预测婴儿期FA的存在和程度,但FA的频谱反映了其文化特征。AD和FA的临床表现实际上可能是特应性和变态反应背后的免疫失调程度的一种表达。
更新日期:2020-02-25
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