BACKGROUND Solutes distribution by the intracranial cerebrospinal fluid (CSF) fluxes along perivascular spaces and through interstitial fluid (ISF) play a key role in the clearance of brain metabolites, with essential functions in maintaining brain homeostasis. OBJECTIVE To investigate the impact of decompressive craniectomy (DC) and cranioplasty (CP) on the efficacy of solutes distribution by the intracranial CSF and ISF flux. METHODS Mice were allocated in 3 groups: sham surgery, DC, and DC followed by CP. The solutes distribution in the brain parenchyma was assessed using T1 magnetic resonance imaging after injection of DOTA-Gadolinium in the cisterna magna. This evaluation was performed at an early time point following DC (after 2 d) and at a later time point (after 15 d). We evaluated the solutes distribution in the whole brain and in the region underneath the DC area. RESULTS Our results demonstrate that the global solutes distribution in the brain parenchyma is impaired after DC in mice, both at early and late time-points. However, there was no impact of DC on the solutes distribution just under the craniectomy. We then provide evidence that this impairment was reversed by CP. CONCLUSION The solute distribution in the brain parenchyma by the CSF and ISF is impaired by DC, a phenomenon reversed by CP.

中文翻译：

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颅骨成形术逆转减压颅骨切除术后脑实质溶质分布功能障碍

背景通过颅内脑脊液 (CSF) 流沿血管周围空间和通过间质液 (ISF) 的溶质分布在脑代谢物的清除中起关键作用，在维持脑稳态方面具有重要功能。目的探讨去骨瓣减压术（DC）和颅骨成形术（CP）对颅内CSF和ISF流量溶质分布效果的影响。方法 将小鼠分为 3 组：假手术组、DC 组和 DC 组，然后是 CP。在大池中注射 DOTA-钆后，使用 T1 磁共振成像评估脑实质中的溶质分布。该评估在 DC 后的早期时间点（2 天后）和较晚的时间点（15 天后）进行。我们评估了整个大脑和 DC 区域下方区域的溶质分布。结果 我们的结果表明，小鼠脑实质中的整体溶质分布在早期和晚期时间点均在 DC 后受损。然而，DC对颅骨切除术下的溶质分布没有影响。然后我们提供证据证明该减值已被 CP 逆转。结论 CSF 和 ISF 在脑实质中的溶质分布受到 DC 的影响，这一现象被 CP 逆转。然后我们提供证据证明该减值已被 CP 逆转。结论 CSF 和 ISF 在脑实质中的溶质分布受到 DC 的影响，这一现象被 CP 逆转。然后我们提供证据证明该减值已被 CP 逆转。结论 CSF 和 ISF 在脑实质中的溶质分布受到 DC 的影响，这一现象被 CP 逆转。