PURPOSE OF REVIEW It is only over the last few decades that the impact of coronary artery disease (CAD) in very young South Asian population has been recognized. There has been a tremendous interest in elucidating the causes behind this phenomenon and these efforts have uncovered several mechanisms that might explain the early onset of CAD in this population. The complete risk profile of very young South Asians being affected by premature CAD still remains unknown. RECENT FINDINGS The existing data fail to completely explain the burden of premature occurrence of CAD in South Asians especially in very young individuals. Results from some studies identified nine risk factors, including low consumption of fruits and vegetables, smoking, alcohol, diabetes, psychosocial factors, sedentary lifestyle, abdominal obesity, hypertension and dyslipidemia as the cause of myocardial infarction in 90% of the patients in this population. Recent large genome-wide association studies have discovered the association of several novel genetic loci with CAD in South Asians. Nonetheless, continued scientific efforts are required to further our understanding of the causal risk factors of CAD in South Asians to address the rising burden of CVD in this vulnerable population. SUMMARY In this review, we discuss established and emerging risk factors of CAD in this population.

中文翻译：

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在非常年轻的南亚人中，心肌梗塞的危险因素。

回顾的目的直到最近几十年，才认识到南亚年轻人口中冠状动脉疾病（CAD）的影响。阐明这种现象背后的原因引起了极大的兴趣，这些努力揭示了几种机制，可以解释这一人群中CAD的早期发作。仍受过早的CAD影响的非常年轻的南亚人的完整风险状况仍然未知。最近的发现现有数据未能完全解释南亚人，特别是年纪轻轻的人中，过早出现CAD的负担。一些研究的结果确定了九种风险因素，包括水果和蔬菜的低摄入量，吸烟，酗酒，糖尿病，社会心理因素，久坐的生活方式，腹部肥胖，高血压和血脂异常是该人群中90％的患者心肌梗死的原因。最近的大型全基因组关联研究发现了南亚人中几种新的基因位点与CAD的关联。尽管如此，仍需要继续的科学努力来加深我们对南亚人CAD的因果风险因素的认识，以解决这一弱势人群中CVD日益增加的负担。总结在这篇综述中，我们讨论了该人群中已确定的和新兴的CAD危险因素。需要持续的科学努力，以加深我们对南亚人CAD的因果风险因素的了解，以解决这一弱势人群中CVD日益增加的负担。总结在这篇综述中，我们讨论了该人群中已确定的和新兴的CAD危险因素。需要持续的科学努力，以加深我们对南亚人CAD的因果风险因素的了解，以解决这一弱势人群中CVD日益增加的负担。总结在这篇综述中，我们讨论了该人群中已确定的和新兴的CAD危险因素。