Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease‐informed machine‐learning,Alzheimer's & Dementia

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Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease‐informed machine‐learning
Alzheimer's & Dementia ( IF 13.0 ) Pub Date : 2020-02-11 , DOI: 10.1002/alz.12032
Nicolai Franzmeier ₁ , Nikolaos Koutsouleris ₂ , Tammie Benzinger _{3,

4} , Alison Goate _{5,

6} , Celeste M Karch _{4,

7,

8} , Anne M Fagan _{4,

7,

9} , Eric McDade _{4,

9} , Marco Duering ₁ , Martin Dichgans _{1,

10,

11} , Johannes Levin _{10,

11,

12} , Brian A Gordon _{4,

13,

14} , Yen Ying Lim ₁₅ , Colin L Masters ₁₅ , Martin Rossor ₁₆ , Nick C Fox ₁₆ , Antoinette O'Connor ₁₆ , Jasmeer Chhatwal ₁₇ , Stephen Salloway ₁₈ , Adrian Danek ₁₂ , Jason Hassenstab _{4,

9,

14} , Peter R Schofield _{19,

20} , John C Morris _{4,

8,

9} , Randall J Bateman _{4,

9} , ₂₁ , ₂₂ , Michael Ewers ₁

Affiliation

Institute for Stroke and Dementia Research, Klinikum der Universität München, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-Universität LMU, Munich, Germany.
Department of Radiology, Washington University in St. Louis, St. Louis, Missouri, USA.
Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ronald M. Loeb Center for Alzheimer's Disease, Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Psychiatry, Washington University in St. Louis, St. Louis, Missouri, USA.
Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA.
Munich Cluster for Systems Neurology, Munich, Germany.
German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.
Department of Neurology, Ludwig-Maximilians-Universität München, Munich, Germany.
Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri, USA.
Department of Psychological and Brain Sciences, Washington University, St. Louis, Missouri, USA.
The Florey Institute, The University of Melbourne, Parkville, Victoria, Australia.
Dementia Research Centre, University College London, Queen Square, London, UK.
Massachusetts General Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
Department of Neurology, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Neuroscience Research Australia, Randwick, New South Wales, Australia.
School of Medical Sciences, University of New South Wales, Sydney, New South Wales, Australia.
ADNI Consortium members are listed in the appendix.
DIAN Consortium members are listed in the appendix.

Developing cross‐validated multi‐biomarker models for the prediction of the rate of cognitive decline in Alzheimer's disease (AD) is a critical yet unmet clinical challenge.

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