MicroRNAs (miRNAs) have been identified in many organisms, and they are essential for gene expression regulation in many critical cellular processes. The expression levels of these genes and miRNAs are closely associated with the progression of diseases such as cancers. Furthermore, survival analysis is a significant indicator for evaluating the criticality of these cellular processes in cancer progression. We established a web tool, miRNA Target Viewer (miR-TV), which integrates 5p-arm and 3p-arm miRNA expression profiles, mRNA target gene expression levels in healthy and cancer populations, and clinical data of cancer patients and their survival information. The developed miR-TV obtained miRNA-seq, mRNA-seq and clinical data from the Cancer Genome Atlas and potential miRNA target gene predictions from miRDB, targetScan and miRanda. The data presentation was implemented using the D3 javascript toolkit. The D3 toolkit is frequently used to provide an easy-to-use interactive interface. Our miR-TV provides a user-friendly and interactive interface, which can be beneficial for biomedical researchers to freely interrogate miRNA expression information and their potential target genes. We believe that such a data visualization bioinformatics tool is excellent for obtaining information from massive biological data. Database URL: http://mirtv.ibms.sinica.edu.tw.

中文翻译：

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miR-TV：交互式microRNA Target Viewer，用于人类癌症研究中的microRNA和靶基因表达询问。

MicroRNA（miRNA）已在许多生物中得到鉴定，它们对于调控许多关键细胞过程中的基因表达至关重要。这些基因和miRNA的表达水平与疾病的发展密切相关，例如癌症。此外，生存分析是评估这些细胞过程在癌症进展中的关键性的重要指标。我们建立了一个网络工具miRNA Target Viewer（miR-TV），该工具整合了5p臂和3p臂miRNA表达谱，健康人群和癌症人群中的mRNA靶基因表达水平以及癌症患者的临床数据及其生存信息。已开发的miR-TV从Cancer Genome Atlas获得了miRNA-seq，mRNA-seq和临床数据，并从miRDB，targetScan和miRanda获得了潜在的miRNA靶基因预测。数据表示是使用D3 javascript工具包实现的。D3工具箱通常用于提供易于使用的交互式界面。我们的miR-TV提供了一个用户友好的交互式界面，这对于生物医学研究人员自由询问miRNA表达信息及其潜在的靶基因可能是有益的。我们认为，这种数据可视化生物信息学工具非常适合从大量生物数据中获取信息。数据库URL：http：//mirtv.ibms.sinica.edu.tw。这对于生物医学研究人员自由询问miRNA表达信息及其潜在靶基因可能是有益的。我们认为，这种数据可视化生物信息学工具非常适合从大量生物数据中获取信息。数据库URL：http：//mirtv.ibms.sinica.edu.tw。这对于生物医学研究人员自由询问miRNA表达信息及其潜在靶基因可能是有益的。我们认为，这种数据可视化生物信息学工具非常适合从大量生物数据中获取信息。数据库URL：http：//mirtv.ibms.sinica.edu.tw。