Disease causative non-coding RNAs (ncRNAs) are of great importance in understanding a disease, for they directly contribute to the development or progress of a disease. Identifying the causative ncRNAs can provide vital implications for biomedical researches. In this work, we updated the long non-coding RNA disease database (LncRNADisease) with long non-coding RNA (lncRNA) causality information with manual annotations of the causal associations between lncRNAs/circular RNAs (circRNAs) and diseases by reviewing related publications. Of the total 11 568 experimental associations, 2297 out of 10 564 lncRNA-disease associations and 198 out of 1004 circRNA-disease associations were identified to be causal, whereas 635 lncRNAs and 126 circRNAs were identified to be causative for the development or progress of at least one disease. The updated information and functions of the database can offer great help to future researches involving lncRNA/circRNA-disease relationship. The latest LncRNADisease database is available at http://www.rnanut.net/lncrnadisease.

中文翻译：

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LncRNADisease中因果关系信息的注释和管理。

导致疾病的非编码RNA（ncRNA）在理解疾病方面非常重要，因为它们直接有助于疾病的发展或进程。鉴定引起的ncRNA可以为生物医学研究提供重要的启示。在这项工作中，我们通过回顾相关出版物，用长非编码RNA（lncRNA）因果关系信息更新了长非编码RNA疾病数据库（LncRNADisease），并手动标注了lncRNA /环状RNA（circRNA）与疾病之间的因果关系。在总共11568个实验关联中，从10 564个lncRNA疾病关联中，有2297个在1004个circRNA疾病关联中，有198个是因果关系，而在635个lncRNA和126个circRNA中，有255个lncRNA和126个circRNA是致病性的。至少一种疾病。数据库的更新信息和功能可以为涉及lncRNA / circRNA-疾病关系的未来研究提供巨大帮助。最新的LncRNADisease数据库可在http://www.rnanut.net/lncrnadisease获得。