ChIP-seq reveals genomic regions where proteins, e.g. transcription factors (TFs) interact with DNA. A substantial fraction of these regions, however, do not contain the cognate binding site for the TF of interest. This phenomenon might be explained by protein-protein interactions and co-precipitation of interacting gene regulatory elements. We uniformly processed 3727 human ChIP-seq data sets and determined the cistrome of 292 TFs, as well as the distances between the TF binding motif centers and the ChIP-seq peak summits. ChIPSummitDB enables the analysis of ChIP-seq data using multiple approaches. The 292 cistromes and corresponding ChIP-seq peak sets can be browsed in GenomeView. Overlapping SNPs can be inspected in dbSNPView. Most importantly, the MotifView and PairShiftView pages show the average distance between motif centers and overlapping ChIP-seq peak summits and distance distributions thereof, respectively. In addition to providing a comprehensive human TF binding site collection, the ChIPSummitDB database and web interface allows for the examination of the topological arrangement of TF complexes genome-wide. ChIPSummitDB is freely accessible at http://summit.med.unideb.hu/summitdb/. The database will be regularly updated and extended with the newly available human and mouse ChIP-seq data sets.

中文翻译：

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ChIPSummitDB：基于ChIP-seq的人类转录因子结合位点及其结合蛋白的拓扑结构数据库。

ChIP-seq揭示了蛋白质（例如转录因子（TFs））与DNA相互作用的基因组区域。然而，这些区域的大部分不包含感兴趣的TF的同源结合位点。这种现象可能是由蛋白质间相互作用以及基因调控元件相互作用引起的。我们统一处理了3727个人类ChIP-seq数据集，并确定了292个TF的色散，以及TF结合基序中心与ChIP-seq峰顶之间的距离。ChIPSummitDB支持使用多种方法分析ChIP-seq数据。可以在GenomeView中浏览292埃和相应的ChIP-seq峰集。可以在dbSNPView中检查重叠的SNP。最重要的是，MotifView和PairShiftView页面分别显示了图案中心与重叠的ChIP-seq峰峰之间的平均距离及其距离分布。除了提供全面的人类TF结合位点集合外，ChIPSummitDB数据库和Web界面还允许检查全基因组TF复合物的拓扑结构。ChIPSummitDB可从http://summit.med.unideb.hu/summitdb/免费访问。该数据库将使用新近可用的人类和小鼠ChIP-seq数据集进行定期更新和扩展。ChIPSummitDB可从http://summit.med.unideb.hu/summitdb/免费访问。该数据库将使用新近可用的人类和小鼠ChIP-seq数据集进行定期更新和扩展。ChIPSummitDB可从http://summit.med.unideb.hu/summitdb/免费访问。该数据库将使用新近可用的人类和小鼠ChIP-seq数据集进行定期更新和扩展。