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Review of the Syntheses and Activities of Some Sulfur-Containing Drugs.
Current Organic Synthesis ( IF 1.7 ) Pub Date : 2020-05-01 , DOI: 10.2174/1570179417666200212113412
Criscieli Taynara Barce Ferro 1 , Beatriz Fuzinato Dos Santos 1 , Caren Daniele Galeano da Silva 1 , George Brand 1 , Beatriz Amaral Lopes da Silva 1 , Nelson Luís de Campos Domingues 1
Affiliation  

Background: Sulfur-containing compounds represent an important class of chemical compounds due to their wide range of biological and pharmaceutical properties. Moreover, sulfur-containing compounds may be applied in other fields, such as biological, organic, and materials chemistry. Several studies on the activities of sulfur compounds have already proven their anti-inflammatory properties and use to treat diseases, such as Alzheimer’s, Parkinson’s, and HIV. Moreover, examples of sulfur-containing compounds include dapsone, quetiapine, penicillin, probucol, and nelfinavir, which are important drugs with known activities.

Objective: This review will focus on the synthesis and application of some sulfur-containing compounds used to treat several diseases, as well as promising new drug candidates.

Conclusion: Due to the variety of compounds containing C-S bonds, we have reviewed the different synthetic routes used toward the synthesis of sulfur-containing drugs and other compounds.



中文翻译:

某些含硫药物的合成和活性综述。

背景:含硫化合物由于其广泛的生物学和药学特性而代表了重要的一类化学化合物。此外,含硫化合物可应用于其他领域,例如生物,有机和材料化学。关于含硫化合物活性的几项研究已经证明它们具有抗炎特性,可用于治疗疾病,例如阿尔茨海默氏症,帕金森氏病和HIV。此外,含硫化合物的实例包括氨苯砜,喹硫平,青霉素,普罗布考和奈非那韦,它们是具有已知活性的重要药物。

目的:本综述将侧重于用于治疗多种疾病的一些含硫化合物的合成和应用,以及有前途的新药候选物。

结论:由于含CS键的化合物种类繁多,我们综述了用于合成含硫药物和其他化合物的不同合成途径。

更新日期:2020-05-01
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