Stimuli Responsive Scaffolds Based on Carboxymethyl Starch and Poly(2-Dimethylaminoethyl Methacrylate) for Anti-Inflammatory Drug Delivery.,Macromolecular Bioscience

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Stimuli Responsive Scaffolds Based on Carboxymethyl Starch and Poly(2-Dimethylaminoethyl Methacrylate) for Anti-Inflammatory Drug Delivery.
Macromolecular Bioscience ( IF 4.4 ) Pub Date : 2020-02-24 , DOI: 10.1002/mabi.201900412
Loredana Elena Nita ₁ , Aurica P Chiriac ₁ , Alina Gabriela Rusu ₁ , Alina Ghilan ₁ , Raluca P Dumitriu ₁ , Maria Bercea ₁ , Nita Tudorachi ₁

Affiliation

The purpose of the study is to obtain multicomponent polyelectrolyte hydrogels with optimal synergistic properties by combining a modified starch with a synthetic one. Thus, new low‐cost and biocompatible semi‐interpenetrating polymer network (semi‐IPN) hydrogels of carboxymethyl starch and poly(2‐dimethylaminoethyl methacrylate) are prepared and investigated. The synthesized hydrogels are studied with respect to the specific characteristics of the gels: swelling kinetics, thermal analysis, viscoelastic characteristics, and their ability to be used as a matrix in drug delivery systems. Therefore, the semi‐IPN gels are loaded with ibuprofen, followed by additional tests to assess the in vitro drug release. The cytocompatibility of the hydrogels with respect to their composition is evaluated in vitro on fibroblast cell culture. The investigations confirm the obtainment of new semi‐IPN hydrogels with pH and temperature responsiveness, good mechanical strength, and potential for use as drug delivery systems or transdermal patches.

中文翻译：

基于羧甲基淀粉和聚（2-二甲基氨基乙基甲基丙烯酸酯）的刺激响应支架，用于抗炎药物的递送。

该研究的目的是通过将改性淀粉与合成淀粉结合，获得具有最佳协同性能的多组分聚电解质水凝胶。因此，制备并研究了羧甲基淀粉和聚甲基丙烯酸2-二甲基氨基乙酯的新型低成本，生物相容性半互穿聚合物网络（semi-IPN）水凝胶。关于凝胶的特定特性，研究了合成的水凝胶：溶胀动力学，热分析，粘弹性特性及其在药物输送系统中用作基质的能力。因此，在半IPN凝胶中加入布洛芬，然后进行其他测试以评估体外药物的释放。在成纤维细胞培养中体外评估水凝胶相对于其组成的细胞相容性。

更新日期：2020-02-24

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