AIMS Alcohol intake has been shown to increase the risk of breast cancer. However, the dose-response analysis of different alcoholic beverages (spirits, wine and beer) is not clear. Our meta-analysis aims to provide a dose-response estimation between different alcohols and breast cancer risk. METHODS Search of PubMed and Web of Science and manual searches were conducted up to 1 December 2018, and summary relative risks (RRs) and attributable risk percentage (ARP) for alcohol intake on the development of breast cancer were calculated. Dose-response meta-analysis modeled relationships between drinking type and breast cancer risk. Sources of heterogeneity were explored, and sensitivity analyses were conducted to test the robustness of findings. RESULTS In total, 22 cohort studies and 45,350 breast cancer cases were included. Current drinkers for ER+ had an increased risk compared with never drinkers. In dose-response analysis, there was a statistically significant linear trend with breast cancer risk increasing gradually by total alcohol and wine dose: when adding 10 g per day, the risk increased by 10.5% (RR = 1.10, 95%CI = 1.08-1.13) in total alcohol and 8.9% (RR = 1.08, 95%CI = 1.04-1.14) in wine. For postmenopausal women, the risk increases by 11.1% (RR = 1.11, 95%CI = 1.09-1.13) with every 10 g of total alcohol increase. Furthermore, the breast cancer alcohol-attributed percentage is higher in Europe than in North America and Asia. CONCLUSIONS The effect of drinking on the incidence of breast cancer is mainly manifested in ER+ breast cancer. Quantitative analysis showed total drinking had a significant risk for breast cancer, especially for postmenopausal women. However, for different alcohols, just wine intake has the similar results.

中文翻译：

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饮料类型和乳腺癌风险对酒精消费的影响：前瞻性队列研究的剂量反应Meta分析。

AIMS研究表明，饮酒会增加患乳腺癌的风险。但是，不同酒精饮料（烈酒，葡萄酒和啤酒）的剂量反应分析尚不清楚。我们的荟萃分析旨在提供不同酒精与乳腺癌风险之间的剂量反应估计。方法截至2018年12月1日，进行PubMed和Web of Science的搜索以及手动搜索，计算出饮酒对乳腺癌发展的总体相对风险（RRs）和归因风险百分比（ARP）。剂量反应荟萃分析模拟了饮酒类型与乳腺癌风险之间的关系。探索了异质性的来源，并进行了敏感性分析以检验结果的稳健性。结果总共包括22项队列研究和45,350例乳腺癌病例。与从未饮酒的人相比，目前使用ER +的饮酒者的风险增加。在剂量反应分析中，存在统计学上显着的线性趋势，乳腺癌风险随酒精和葡萄酒总量的增加而逐渐增加：每天添加10 g时，乳腺癌的风险增加10.5％（RR = 1.10，95％CI = 1.08-总酒精度为1.13），葡萄酒则为8.9％（RR = 1.08，95％CI = 1.04-1.14）。对于绝经后妇女，每增加10克酒精总摄入量，风险就会增加11.1％（RR = 1.11，95％CI = 1.09-1.13）。此外，欧洲的乳腺癌酒精归因百分比高于北美和亚洲。结论饮酒对乳腺癌发病率的影响主要表现在ER +乳腺癌中。定量分析显示，全面饮酒有很大的乳腺癌风险，尤其是对于绝经后妇女。