In this paper, we reported an efficient protocol for hydration of aryl(hetero) and alkyl nitriles toward primary amides with 0.1 equiv. NaOH in NH3·H2O-DMSO under mild conditions. Various substituted nitriles are smoothly converted to the corresponding amides with good to excellent isolated yields. Gram-scale reactions were also performed to produce the desired products in high yields. In addition, the excessive hydrolysis of the nitrile to form the corresponding carboxylic acid was also achieved with increasing the amount of NaOH and prolonging the reaction time.

中文翻译：

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在 NH3·H2O-DMSO 混合物中，不含过渡金属的 NaOH 催化腈水合生成伯酰胺。

在本文中，我们报道了一种有效的方案，用于将芳基（杂）和烷基腈水合为 0.1 当量的伯酰胺。NaOH 在温和条件下溶于 NH3·H2O-DMSO。各种取代的腈以良好到极好的分离产率顺利转化为相应的酰胺。还进行了克级反应以高产率生产所需的产物。此外，随着NaOH用量的增加和反应时间的延长，腈也可以过度水解生成相应的羧酸。