Introduction: From a biopharmaceutical standpoint, the skin is recognized as an interesting route for drug delivery. In general, small molecules are able to penetrate the stratum corneum, the outermost layer of the skin. In contrast, the delivery of larger molecules, such as peptides and proteins, remains a challenge. Nanoparticles have been exploited not only to enhance skin penetration of drugs but also to expand the range of molecules to be clinically used.Areas covered: This review focus on Solid lipid nanoparticles (SLN) and Nanostructured lipid carriers (NLC) for skin administration. We discuss the selection criteria for lipids, surfactants, and surface modifiers commonly in use in SLN/NLC, their production techniques, and the range of drugs loaded in these lipid nanoparticles for the treatment of skin disorders.Expert opinion: Depending on the lipid and surfactant composition, different nanoparticle morphologies can be generated. Both SLN and NLC are composed of lipids that resemble those of the skin and sebum, which contribute to their enhanced biocompatibility, with limited toxicological risk. SLN and NLC can be loaded with very chemically different drugs, may provide a tunable release profile, can be produced in a sterilized environment, and be scaled-up without the need for organic solvents.

中文翻译：

---

SLN和NLC用于局部，皮肤和透皮给药。

简介：从生物制药的角度来看，皮肤被认为是药物输送的有趣途径。通常，小分子能够穿透皮肤的最外层角质层。相反，较大的分子，如肽和蛋白质的递送仍然是挑战。纳米颗粒不仅被用于增强药物对皮肤的渗透性，而且还扩大了临床上使用的分子的范围。涵盖的领域：本综述侧重于用于皮肤给药的固体脂质纳米颗粒（SLN）和纳米结构脂质载体（NLC）。我们讨论了SLN / NLC中常用的脂质，表面活性剂和表面改性剂的选择标准，其生产技术以及这些脂质纳米颗粒中用于治疗皮肤疾病的药物范围。专家意见：取决于脂质和表面活性剂的组成，可以产生不同的纳米颗粒形态。SLN和NLC均由类似于皮肤和皮脂的脂质组成，这些脂质有助于增强其生物相容性，并具有有限的毒理学风险。SLN和NLC可以装载化学性质非常不同的药物，可以提供可调的释放曲线，可以在无菌环境中生产，并且可以按比例放大，而无需有机溶剂。