Introduction: Multipurpose prevention technologies (MPTs) have the potential to avert multiple concomitant sexual and reproductive health issues in women such as sexually transmitted infections and unintended pregnancy. MPTs incorporate one or more active pharmaceutical ingredients in a single product, which adds more convenience for users and may promote increased adherence. Various vaginal dosage forms/delivery systems have been studied for designing MPTs. However, several challenges remain that are mainly related to requirements of individual drugs or intended multiple applications.Areas covered: This review focuses on the emerging need and development of vaginal MPTs. It illustrates numerous examples that are currently in the preclinical and clinical development pipeline, highlighting the concept behind vaginal MPTs. The article also highlights the challenges associated with formulation design and development, including regulatory issues that need to be addressed.Expert opinion: Vaginal MPTs present great potential to empower women with novel, efficient, and safe products for protection against sexually transmitted infections and unintended pregnancy. However, several technological issues and regulatory gaps still need to be addressed in order to meet real-world needs.

中文翻译：

---

阴道多用途预防技术：增强妇女的性健康和生殖健康的有前途的方法。

简介：多功能预防技术（MPT）有潜力避免女性同时发生的性健康和生殖健康问题，例如性传播感染和意外怀孕。MPT将一种或多种活性药物成分掺入单一产品中，这为用户增加了更多便利，并且可能会提高依从性。为了设计MPT，已经研究了各种阴道剂型/递送系统。但是，仍然存在一些挑战，这些挑战主要与单个药物的需求或预期的多种用途有关。涵盖的领域：本综述重点关注阴道MPT的新兴需求和发展。它举例说明了目前在临床前和临床开发过程中的许多实例，突出了阴道MPT背后的概念。文章还重点介绍了与配方设计和开发相关的挑战，包括需要解决的监管问题。专家意见：阴道MPT具有巨大的潜力，可以为妇女提供新颖，有效和安全的产品，以防止性传播感染和意外怀孕。但是，为了满足实际需求，仍然需要解决一些技术问题和监管空白。