Many studies have shown that urokinase plasminogen activator (uPA) is causally involved in promoting cancer invasion and metastasis. Thus, monitoring uPA levels could be very useful in cancer diagnosis, identification of initial metastasis, and guiding cancer treatment. Here, the authors developed a novel and scalable uPA sensor based on a graphene-gold nanoparticle platform that uses fluorescence of quantum dots to rapidly (<1 h) detect uPA up to 100 pM. Indeed, the authors' sensor is highly selective and showed an ability to sense up to 100 pM uPA even in the presence of complex biological milieu such as the fetal bovine serum.

中文翻译：

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使用柔性纸基石墨烯-金平台快速检测尿激酶纤溶酶原激活剂。


许多研究表明，尿激酶纤溶酶原激活剂（uPA）与促进癌症侵袭和转移有因果关系。因此，监测 uPA 水平对于癌症诊断、识别初始转移和指导癌症治疗非常有用。在这里，作者开发了一种基于石墨烯-金纳米粒子平台的新颖且可扩展的 uPA 传感器，该传感器使用量子点荧光快速（<1 小时）检测高达 100 pM 的 uPA。事实上，作者的传感器具有高度选择性，即使在存在复杂的生物环境（例如胎牛血清）的情况下也能检测高达 100 pM uPA。