Many parasitic infections stimulate antibody responses in their mammalian hosts. The ability of these antibodies to protect against disease varies markedly. Research has revealed that functional properties of antibodies determine their role in protection against parasites. Investigations of antibodies against Plasmodium spp. have demonstrated a variety of functional activities, ranging from invasion inhibition and parasite growth inhibition to antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity. These activities have been demonstrated with a large variety of parasite molecules at multiple life cycle stages, highlighting the importance of functional antibody responses in malaria. Other parasitic infections have not yet been investigated in similar detail, but these mechanisms are likely to operate in nonmalarial parasitic infections as well. In this report, we review data on the role of functional antibody responses in protection from parasitic infections, highlighting discoveries in malaria, a parasite for which our knowledge base is the most advanced.

中文翻译：

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抗体效应物在疟疾和其他寄生虫疾病中的作用：几根针和许多干草堆。

许多寄生虫感染会刺激其哺乳动物宿主中的抗体反应。这些抗体预防疾病的能力明显不同。研究表明，抗体的功能特性决定了其在预防寄生虫中的作用。抗疟原虫属物种的抗体的研究。已经证明了多种功能活性，从入侵抑制和寄生虫生长抑制到抗体依赖性细胞的吞噬作用和抗体依赖性细胞的细胞毒性。在多个生命周期阶段，大量寄生虫分子已证明了这些活性，突出了功能性抗体应答在疟疾中的重要性。尚未对其他寄生虫感染进行类似的详细调查，但是这些机制也可能在非疟疾寄生虫感染中起作用。在本报告中，我们回顾了功能性抗体应答在预防寄生虫感染中的作用的数据，重点介绍了疟疾的发现，疟疾是我们知识库中最先进的寄生虫。