The occurrence of neurodegenerative disease is increasingly raised. From physiopathological aspect, the emergence of auto-reactive antibodies against the nervous system antigens contributes to de-myelination in Multiple sclerosis (MS). These features cause the nervous system dysfunction. The follow-up of molecular alterations could give us a real-state vision about intracellular status during pathological circumstances. In this review, we focus on the autophagic response during MS progression and further understand the relationship between autophagy and MS and its modulatory effect on the MS evolution. The authors reviewed studies published on the autophagy status in neurodegenerative disease and on the autophagy modulation in MS prognosis, diagnosis, and possible therapies. The inevitable role of autophagy was shown in the early-stage progression of MS. Due to critical role of autophagy in different stage of cell activity in nervous system, the distinct role of autophagy should not be neglected in the development, pathogenesis, and treatment of MS.

中文翻译：

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神经退行性疾病中自噬信号通路的真实状态；专注于多发性硬化症。

神经退行性疾病的发生越来越多。从生理病理学方面，针对神经系统抗原的自身反应性抗体的出现有助于多发性硬化症（MS）的脱髓鞘。这些特征导致神经系统功能障碍。分子变化的随访可以使我们对病理情况下细胞内状态有一个真实的了解。在这篇综述中，我们着重于MS进展过程中的自噬反应，并进一步了解自噬与MS之间的关系及其对MS进化的调节作用。作者回顾了有关神经退行性疾病中自噬状态以及MS预后，诊断和可能疗法中自噬调节的研究。自噬的不可避免的作用显示在MS的早期进展中。由于自噬在神经系统细胞活动不同阶段的关键作用，因此自噬的独特作用在MS的发展，发病机制和治疗中不应忽略。