Dexmedetomidine (DEX) was widely used in clinical work. However, the effectiveness of DEX on postoperative cognitive dysfunction (POCD) was still need to be confirmed. The aim of this meta-analysis was to explore whether DEX can reduce the incidence of POCD on the first day and seventh postoperative day. The results showed that lower incidence of POCD associated with DEX treatment on the first (odds ratio [OR]: 0.41; 95% confidence interval [CI]: 0.31-0.54) or seventh postoperative day (OR: 0.53; 95% CI: 0.36-0.77). Mini-Mental State Examination scores on the first (mean difference [MD]: 4.67; 95% CI: 1.72-7.63) and seventh postoperative days (MD: 3.71; 95% CI: 2.51-4.90) were higher in DEX use group than that in physiological saline group. Meanwhile, neuron-specific enolase (NSE; MD: -3.99; 95% CI: -6.20 to -1.78) and interleukin 6 (IL-6) levels (MD: -17.53; 95% CI: -21.51 to -13.54) on the first postoperative day in DEX group were lower than that in the physiological saline group. This meta-analysis suggested that DEX use could reduce the risk of POCD and the reduction in levels of NSE and IL-6 can improve long-term cognitive dysfunction and anti-inflammation.

中文翻译：

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右美托咪定可降低术后患者的IL-6水平和术后认知功能障碍的风险：一项荟萃分析。

右美托咪定（DEX）被广泛用于临床工作。然而，仍需要确认DEX对术后认知功能障碍（POCD）的有效性。这项荟萃分析的目的是探讨DEX是否可以降低术后第一天和第七天POCD的发生率。结果表明，术后第一天（赔率[OR]：0.41； 95％置信区间[CI]：0.31-0.54）或术后第七天（OR：0.53； 95％CI：0.36）与DEX治疗相关的POCD发生率较低-0.77）。DEX使用组在第一天（平均差异[MD]：4.67； 95％CI：1.72-7.63）和第七天（MD：3.71； 95％CI：2.51-4.90）的小心理状态评分高于在生理盐水组。同时，神经元特异性烯醇化酶（NSE； MD：-3.99； 95％CI：-6.20至-1。DEX组术后第一天的白细胞介素6（IL-6）水平（MD：-17.53； 95％CI：-21.51至-13.54）低于生理盐水组（78）和白介素6（IL-6）水平。这项荟萃分析表明，使用DEX可以降低POCD的风险，而降低NSE和IL-6的水平可以改善长期的认知功能障碍和抗炎作用。