BACKGROUND Dietary protein and amino acid intake and composition can modulate immune function. OBJECTIVES To evaluate the effects of high-protein intake and arginine and ornithine supplementation on feline immune cells. ANIMALS Ten healthy cats. METHODS Experimental study. Cats received a high-protein basal diet as a single daily meal. A crossover design was applied with treatments being basal diet (w/o); basal diet with arginine supplementation (+50, 75, 100% compared to the arginine provision by the basal diet; Arg 1-3); and basal diet with ornithine supplementation (+100, 150, 200% compared to the arginine provision by the basal diet; Orn 1-3). Blood samples were collected at the end of each 11-day treatment period. RESULTS Mitogen-stimulated proliferative activity of blood leukocytes revealed a quadratic effect for the dietary supplementation of arginine (P = .02) and ornithine (P = .03) (means for ConA-stimulation: w/o = 6.96; Arg 1 = 9.31; Arg 2 = 11.4; Arg 3 = 8.04; Orn 1 = 15.4; Orn 2 = 9.43; Orn 3 = 9.28; pooled SEM: 0.96). The number (% gated) of phagocytic granulocytes linearly decreased with increasing dietary concentrations of arginine (P = .05) and ornithine (P = .03) (means: w/o = 95.5; Arg 1 = 93.0; Arg 2 = 92.5; Arg 3 = 92.6; Orn 1 = 92.6; Orn 2 = 92.6; Orn 3 = 91.5; pooled SEM = 0.44). CONCLUSIONS AND CLINICAL IMPORTANCE This study could demonstrate immunomodulating properties of dietary arginine and ornithine in cats.

中文翻译：

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补充高蛋白饮食的精氨酸和鸟氨酸对成年猫选择的细胞免疫变量的影响。

背景技术饮食中蛋白质和氨基酸的摄入量及组成可以调节免疫功能。目的评估高蛋白摄入以及精氨酸和鸟氨酸补充对猫免疫细胞的影响。动物十只健康的猫。方法实验研究。猫每天单顿进食高蛋白基础饮食。采用交叉设计，基础饮食治疗（无汤）；补充精氨酸的基础饮食（与基础饮食提供的精氨酸相比增加了50％，75％，100％； Arg 1-3）；以及添加鸟氨酸的基础饮食（与基础饮食提供的精氨酸相比增加了100％，150％，200％； Orn 1-3）。在每个11天治疗期结束时收集血液样本。结果丝裂原刺激的白血球增殖活性表明，膳食补充精氨酸（P = .02）和鸟氨酸（P = .03）有二次效应（ConA刺激的平均值：w / o = 6.96； Arg 1 = 9.31 ； Arg 2 ＝ 11.4； Arg 3 ＝ 8.04； Orn 1 ＝ 15.4； Orn 2 ＝ 9.43； Orn 3 ＝ 9.28；合并SEM：0.96。吞噬性粒细胞的数量（门控百分比）随着日粮中精氨酸（P = .05）和鸟氨酸（P = .03）浓度的增加而线性减少（平均值：w / o = 95.5； Arg 1 = 93.0； Arg 2 = 92.5； Arg 3 = 92.6； Orn 1 = 92.6； Orn 2 = 92.6； Orn 3 = 91.5；合并SEM = 0.44）。结论和临床意义这项研究可以证明猫中饮食精氨酸和鸟氨酸的免疫调节特性。精氨酸3 = 8.04; Orn 1 = 15.4; Orn 2 = 9.43; Orn 3 = 9.28；合并SEM：0.96）。吞噬性粒细胞的数量（门控百分比）随着日粮中精氨酸（P = .05）和鸟氨酸（P = .03）浓度的增加而线性降低（平均值：w / o = 95.5； Arg 1 = 93.0； Arg 2 = 92.5； Arg 3 = 92.6； Orn 1 = 92.6； Orn 2 = 92.6； Orn 3 = 91.5；合并SEM = 0.44）。结论和临床意义这项研究可以证明猫中饮食精氨酸和鸟氨酸的免疫调节特性。精氨酸3 = 8.04; Orn 1 = 15.4; Orn 2 = 9.43；Orn 3 = 9.28；合并SEM：0.96）。吞噬性粒细胞的数量（门控百分比）随着日粮中精氨酸（P = .05）和鸟氨酸（P = .03）浓度的增加而线性降低（平均值：w / o = 95.5； Arg 1 = 93.0； Arg 2 = 92.5； Arg 3 = 92.6； Orn 1 = 92.6； Orn 2 = 92.6； Orn 3 = 91.5；合并SEM = 0.44）。结论和临床意义这项研究可以证明猫中饮食精氨酸和鸟氨酸的免疫调节特性。