Although endovascular or surgical treatment has been performed for preventing the rupture of saccular cerebral aneurysms (sCA), in some patients, the aneurysms may recur and require retreatment. We aimed to investigate the clinical and radiological outcomes of treating recurrent sCA. We retrospectively evaluated the data of 52 patients with 60 recurrent sCAs who were retreated and 1534 patients with 1817 sCAs who received initial treatment. The primary outcome was a recurrence of the aneurysm. Secondary outcomes were an additional treatment, rupture after treatment, and a neurological worsening, which was defined as an increase of 1 or more scores using the modified Rankin Scale at 12-month. Safety outcomes included postoperative ischemic and hemorrhagic complications. We compiled the 120 (60 each) propensity score-matched cohort based on a propensity score for the treatment of recurrent sCA. In the propensity score-matched cohort, recurrence after treatment was observed in 25% and 6.7% of cases in the retreatment and initial treatment groups, respectively. The odds ratio of recurrence after treatment was 4.7 (95% CI, 1.4-15; P = 0.011). The secondary and safety outcomes were not significantly different between the two groups. This study showed that the treatment of recurrent sCA was a risk factor for recurrence after treatment but not for additional treatment, rupture after treatment, or neurological worsening. Although decision-making regarding the treatment varies depending on the institutional protocols and personal experience of the physicians, endovascular or surgical retreatment could be performed without hesitation.

中文翻译：

---

复发性囊状脑动脉瘤的再治疗结果：倾向评分匹配分析。

尽管已进行血管内或外科治疗以防止眼球囊性脑动脉瘤（sCA）破裂，但在某些患者中，动脉瘤可能会复发并需要重新治疗。我们旨在调查治疗复发性sCA的临床和放射学结果。我们回顾性评估了52例复发的60例sCA的患者和1534例初次治疗的1817 sCA的数据。主要结果是动脉瘤复发。次要结果是另外的治疗，治疗后破裂和神经系统恶化，这定义为使用改良的Rankin量表在12个月时得分增加1或更多。安全性结果包括术后缺血性和出血性并发症。我们根据倾向评分对复发性sCA的治疗编制了120个倾向评分匹配的队列（每组60个）。在倾向评分匹配的队列中，在再治疗组和初始治疗组中分别观察到25％和6.7％的病例在治疗后复发。治疗后复发的比值比为4.7（95％CI，1.4-15； P = 0.011）。两组的次要和安全性结果无显着差异。这项研究表明，复发性sCA的治疗是治疗后复发的危险因素，而不是其他治疗，治疗后破裂或神经系统恶化的危险因素。尽管有关治疗的决策会根据机构规程和医生的个人经验而有所不同，