Cardiovascular disease (CVD) is the leading cause of death throughout the world. A major risk factor for CVD is platelet aggregation. Various plant extracts exhibit anti-aggregatory action in vitro. The dietary intake of traditional plant crops such as quinoa (Chenopodium quinoa Willd) and lupin (Lupinus spp., Fabaceae family), highly recognized for their high nutritional value, is increasing worldwide. The aim of the study was to assay possible antiplatelet effects of quinoa and lupin bean extracts in vitro. The proximate chemical composition of quinoa grains and the three most widely known lupin cultivars: blue (L. angustifolius), yellow (L. luteus or mutabilis) and white (L. albus) grown in Chile were analyzed. The anti-aggregation activity of the ethanol extracts of the crops was assayed using flow cytometry in ADP-stimulated human platelets, and their inhibition of the maximal platelet aggregation was measured. All the lupin extracts exhibited a significant anti-aggregatory effect (p < 0.0001), while quinoa extracts did not exert this effect compared to control platelets. In conclusion, lupin beans extracts exhibited an anti-aggregatory effect on activated human platelets.

中文翻译：

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藜麦（Chenopodium quinoa Willd.）和羽扇豆（羽扇豆属）提取物对人血小板聚集的体外测定

心血管疾病 (CVD) 是全世界死亡的主要原因。心血管疾病的一个主要危险因素是血小板聚集。各种植物提取物在体外表现出抗聚集作用。藜麦（Chenopodium quinoa Willd）和羽扇豆（羽扇豆属，豆科）等传统植物作物的膳食摄入量因其高营养价值而受到高度认可，在全球范围内不断增加。该研究的目的是在体外测定藜麦和羽扇豆提取物可能的抗血小板作用。分析了藜麦谷物和三种最广为人知的羽扇豆栽培品种：蓝色（L. angustifolius）、黄色（L. luteus 或 mutabilis）和白色（L. albus）生长在智利的化学成分。使用流式细胞术在 ADP 刺激的人血小板中测定了作物乙醇提取物的抗聚集活性，并测量它们对最大血小板聚集的抑制作用。所有羽扇豆提取物都表现出显着的抗聚集作用（p < 0.0001），而与对照血小板相比，藜麦提取物没有发挥这种作用。总之，羽扇豆提取物对活化的人血小板具有抗聚集作用。