Epigenetic mechanisms govern the transcription of the genome. Research with model systems reveals that environmental conditions can directly influence epigenetic mechanisms that are associated with interindividual differences in gene expression in brain and neural function. In this review, we provide a brief overview of epigenetic mechanisms and research with relevant rodent models. We emphasize more recent translational research programs in epigenetics as well as the challenges inherent in the integration of epigenetics into developmental and clinical psychology. Our objectives are to present an update with respect to the translational relevance of epigenetics for the study of psychopathology and to consider the state of current research with respect to its potential importance for clinical research and practice in mental health.

中文翻译：

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表观遗传学、发育和精神病理学。

表观遗传机制控制基因组的转录。对模型系统的研究表明，环境条件可以直接影响与大脑和神经功能中基因表达的个体差异相关的表观遗传机制。在这篇综述中，我们简要概述了表观遗传机制和相关啮齿动物模型的研究。我们强调最近的表观遗传学转化研究项目，以及表观遗传学整合到发育和临床心理学中所固有的挑战。我们的目标是提供关于表观遗传学在精神病理学研究中的转化相关性的更新，并考虑当前研究的状态，考虑其对心理健康临床研究和实践的潜在重要性。