当前位置: X-MOL 学术Int. J. Dev. Neurosci. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Early weaning modulates eating behavior and promotes hypofunction of the serotonergic (5HT) system in juvenile male rats
International Journal of Developmental Neuroscience ( IF 1.7 ) Pub Date : 2020-03-09 , DOI: 10.1002/jdn.10018
Gabriel Araújo Tavares 1, 2 , Larissa Cavalcanti do Amaral Almeida 3 , Julliet Araújo de Souza 3 , Felipe Leitão de Souza 1 , Glauber Rudá Feitosa Braz 3 , Bruna Times Silva 1 , Andresa Mayara da Silva Santos 1 , Cláudia Jacques Lagranha 3, 4 , Sandra Lopes de Souza 1, 3
Affiliation  

Early life stress (ELS) has been associated with developmental impairments. Early weaning (EW) is a postnatal stress model consisting of interruption of lactation and maternal care. The 5HT‐system has been associated with neurobehavioral modulations promoted by ELS. Thus, the present work aims to investigate the effects of early weaning on feeding behavior and serotonergic system of juvenile male rats. For this, rats were submitted to early (PND15) or natural (PND30) weaning and had the body weight, food intake in circadian phases, and food intake in response to fenfluramine assessed. mRNA expression of serotoninergic receptors (5HT1A and 5HT2C) and transporter (SERT) was assessed in the hypothalamus and brainstem, as well as NPY and POMC mRNA expression in hypothalamus. The results show that early weaning promoted changes in the percentage of weight gain during lactation period and increase in body weight at PND40. It was also observed that EW promoted increase and decrease in food intake in light and dark phase, respectively, and leads to a decreased action of fenfluramine on inhibition of food intake. In addition, early weaning promoted increased NPY and SERT mRNA expression in the hypothalamus and 5HT2C in the brainstem. Together, the data indicate that the stress caused by early weaning impairs the eating behavior of juvenile male rats through hypofunction of the 5HT‐system.

中文翻译:

早期断奶调节幼年雄性大鼠的进食行为并促进血清素 (5HT) 系统功能减退

早期生活压力 (ELS) 与发育障碍有关。早期断奶 (EW) 是一种产后压力模型,包括中断哺乳和产妇护理。5HT 系统与 ELS 促进的神经行为调节有关。因此,目前的工作旨在研究早期断奶对幼年雄性大鼠摄食行为和血清素能系统的影响。为此,大鼠接受早期 (PND15) 或自然 (PND30) 断奶,并评估体重、昼夜节律阶段的食物摄入量和对芬氟拉明的食物摄入量。评估了下丘脑和脑干中血清素受体(5HT1A 和 5HT2C)和转运蛋白 (SERT) 的 mRNA 表达,以及下丘脑中 NPY 和 POMC 的 mRNA 表达。结果表明,早期断奶促进了泌乳期体重增加百分比的变化和 PND40 时体重的增加。还观察到EW分别促进了明、暗阶段食物摄入的增加和减少,并导致芬氟拉明抑制食物摄入的作用降低。此外,早期断奶促进了下丘脑中 NPY 和 SERT mRNA 表达的增加,以及脑干中 5HT2C 的表达。总之,这些数据表明,早期断奶引起的压力会通过 5HT 系统功能减退损害幼年雄性大鼠的进食行为。并导致芬氟拉明抑制食物摄入的作用降低。此外,早期断奶促进了下丘脑中 NPY 和 SERT mRNA 表达的增加以及脑干中 5HT2C 的表达。总之,这些数据表明,早期断奶引起的压力会通过 5HT 系统功能减退损害幼年雄性大鼠的进食行为。并导致芬氟拉明抑制食物摄入的作用降低。此外,早期断奶促进了下丘脑中 NPY 和 SERT mRNA 表达的增加,以及脑干中 5HT2C 的表达。总之,这些数据表明,早期断奶引起的压力会通过 5HT 系统功能减退损害幼年雄性大鼠的进食行为。
更新日期:2020-03-09
down
wechat
bug