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Comparative efficacy of antimicrobial treatments in dairy cows at dry-off to prevent new intramammary infections during the dry period or clinical mastitis during early lactation: a systematic review and network meta-analysis
Animal Health Research Reviews ( IF 4.3 ) Pub Date : 2020-02-21 , DOI: 10.1017/s1466252319000239 C B Winder 1 , J M Sargeant 1, 2 , D Hu 3 , C Wang 3 , D F Kelton 1 , S J Leblanc 1 , T F Duffield 1 , J Glanville 4 , H Wood 4 , K J Churchill 2 , J Dunn 2 , M D Bergevin 2 , K Dawkins 2 , S Meadows 2 , B Deb 2 , M Reist 2 , C Moody 2 , A M O'Connor 3
Animal Health Research Reviews ( IF 4.3 ) Pub Date : 2020-02-21 , DOI: 10.1017/s1466252319000239 C B Winder 1 , J M Sargeant 1, 2 , D Hu 3 , C Wang 3 , D F Kelton 1 , S J Leblanc 1 , T F Duffield 1 , J Glanville 4 , H Wood 4 , K J Churchill 2 , J Dunn 2 , M D Bergevin 2 , K Dawkins 2 , S Meadows 2 , B Deb 2 , M Reist 2 , C Moody 2 , A M O'Connor 3
Affiliation
A systematic review and network meta-analysis were conducted to assess the relative efficacy of antimicrobial therapy given to dairy cows at dry-off. Eligible studies were controlled trials assessing the use of antimicrobials compared to no treatment or an alternative treatment, and assessed one or more of the following outcomes: incidence of intramammary infection (IMI) at calving, incidence of IMI during the first 30 days in milk (DIM), or incidence of clinical mastitis during the first 30 DIM. Databases and conference proceedings were searched for relevant articles. The potential for bias was assessed using the Cochrane Risk of Bias 2.0 algorithm. From 3480 initially identified records, 45 trials had data extracted for one or more outcomes. Network meta-analysis was conducted for IMI at calving. The use of cephalosporins, cloxacillin, or penicillin with aminoglycoside significantly reduced the risk of new IMI at calving compared to non-treated controls (cephalosporins, RR = 0.37, 95% CI 0.23–0.65; cloxacillin, RR = 0.55, 95% CI 0.38–0.79; penicillin with aminoglycoside, RR = 0.42, 95% CI 0.26–0.72). Synthesis revealed challenges with a comparability of outcomes, replication of interventions, definitions of outcomes, and quality of reporting. The use of reporting guidelines, replication among interventions, and standardization of outcome definitions would increase the utility of primary research in this area.
中文翻译：
奶牛在干奶期抗菌治疗预防干奶期新的乳房内感染或泌乳早期临床乳腺炎的比较疗效：系统评价和网络荟萃分析
进行了系统评价和网络荟萃分析，以评估在干奶时对奶牛进行抗菌治疗的相对疗效。符合条件的研究是评估抗菌药物使用与不治疗或替代治疗相比的对照试验，并评估以下一项或多项结果：产犊时乳房内感染 (IMI) 的发生率、乳汁中前 30 天的 IMI 发生率( DIM)，或前 30 DIM 期间临床乳腺炎的发生率。在数据库和会议论文集中搜索相关文章。使用 Cochrane Risk of Bias 2.0 算法评估潜在的偏倚。从最初确定的 3480 条记录中，45 项试验提取了一项或多项结果的数据。对产犊时的 IMI 进行了网络荟萃分析。使用头孢菌素、氯唑西林、与未治疗的对照组相比，或青霉素加氨基糖苷类显着降低了产犊时新发 IMI 的风险（头孢菌素，RR = 0.37, 95% CI 0.23–0.65；氯唑西林，RR = 0.55, 95% CI 0.38–0.79；青霉素加氨基糖苷类， RR = 0.42, 95% CI 0.26–0.72)。综合揭示了结果的可比性、干预措施的复制、结果的定义和报告质量方面的挑战。报告指南的使用、干预措施之间的复制以及结果定义的标准化将增加该领域初级研究的效用。综合揭示了结果的可比性、干预措施的复制、结果的定义和报告质量方面的挑战。报告指南的使用、干预措施之间的复制以及结果定义的标准化将增加该领域初级研究的效用。综合揭示了结果的可比性、干预措施的复制、结果的定义和报告质量方面的挑战。报告指南的使用、干预措施之间的复制以及结果定义的标准化将增加该领域初级研究的效用。
更新日期：2020-02-21
中文翻译：
奶牛在干奶期抗菌治疗预防干奶期新的乳房内感染或泌乳早期临床乳腺炎的比较疗效：系统评价和网络荟萃分析
进行了系统评价和网络荟萃分析，以评估在干奶时对奶牛进行抗菌治疗的相对疗效。符合条件的研究是评估抗菌药物使用与不治疗或替代治疗相比的对照试验，并评估以下一项或多项结果：产犊时乳房内感染 (IMI) 的发生率、乳汁中前 30 天的 IMI 发生率( DIM)，或前 30 DIM 期间临床乳腺炎的发生率。在数据库和会议论文集中搜索相关文章。使用 Cochrane Risk of Bias 2.0 算法评估潜在的偏倚。从最初确定的 3480 条记录中，45 项试验提取了一项或多项结果的数据。对产犊时的 IMI 进行了网络荟萃分析。使用头孢菌素、氯唑西林、与未治疗的对照组相比，或青霉素加氨基糖苷类显着降低了产犊时新发 IMI 的风险（头孢菌素，RR = 0.37, 95% CI 0.23–0.65；氯唑西林，RR = 0.55, 95% CI 0.38–0.79；青霉素加氨基糖苷类， RR = 0.42, 95% CI 0.26–0.72)。综合揭示了结果的可比性、干预措施的复制、结果的定义和报告质量方面的挑战。报告指南的使用、干预措施之间的复制以及结果定义的标准化将增加该领域初级研究的效用。综合揭示了结果的可比性、干预措施的复制、结果的定义和报告质量方面的挑战。报告指南的使用、干预措施之间的复制以及结果定义的标准化将增加该领域初级研究的效用。综合揭示了结果的可比性、干预措施的复制、结果的定义和报告质量方面的挑战。报告指南的使用、干预措施之间的复制以及结果定义的标准化将增加该领域初级研究的效用。
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