A systematic review and network meta-analysis (MA) was conducted to address the question, ‘What is the efficacy of bacterial vaccines to prevent respiratory disease in swine?’ Four electronic databases and the grey literature were searched to identify clinical trials in healthy swine where at least one intervention arm was a commercially available vaccine for one or more bacterial pathogens associated with respiratory disease in swine, including Mycoplasma hyopneumoniae, Actinobacillus pleuropneumonia, Actinobacillus suis, Bordetella bronchiseptica, Pasteurella multocida, Stretococcus suis, Haemophils parasuis, and Mycoplasma hyorhinis. To be eligible, trials had to measure at least one of the following outcomes: incidence of clinical morbidity, mortality, lung lesions, or total antibiotic use. There were 179 eligible trials identified in 146 publications. Network MA was undertaken for morbidity, mortality, and the presence or absence of non-specific lung lesions. However, there was not a sufficient body of research evaluating the same interventions and outcomes to allow a meaningful synthesis of the comparative efficacy of the vaccines. To build this body of research, additional rigor in trial design and analysis, and detailed reporting of trial methods and results are warranted.

中文翻译：

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细菌疫苗预防猪呼吸道疾病的功效：系统评价和网络荟萃分析

进行了系统评价和网络荟萃分析 (MA) 以解决“细菌疫苗预防猪呼吸道疾病的功效是什么？”的问题。搜索了四个电子数据库和灰色文献，以确定健康猪的临床试验，其中至少一个干预组是针对一种或多种与猪呼吸道疾病相关的细菌病原体的市售疫苗，包括猪肺炎支原体,胸膜肺炎放线杆菌,猪放线杆菌,支气管败血博德特氏菌,多杀巴氏杆菌,猪链球菌,副猪嗜血杆菌， 和猪鼻支原体. 为了符合条件，试验必须至少测量以下结果之一：临床发病率、死亡率、肺部病变或抗生素使用总量。在 146 篇出版物中确定了 179 项符合条件的试验。对发病率、死亡率和是否存在非特异性肺部病变进行网络 MA。然而，没有足够的研究来评估相同的干预措施和结果，以便对疫苗的比较功效进行有意义的综合。为建立这一研究体系，试验设计和分析更加严格，试验方法和结果的详细报告是必要的。