Danhong Huayu Koufuye (DHK), an effective Chinese medicine preparation, is mainly used for the treatment of blurred vision and sudden blindness caused by qi stagnation and blood stasis, as well as the absorption period of central retinal vein occlusion. However, the current quality standard is relatively low, only stipulating the content of protocatechualdehyde. Chemical transitivity is the basis for discovering quality markers and is used in quality process control of Chinese medicines. Herein, the chemical profiles of seven medicinal herbs, DHK and dosed rat plasma were comprehensively analyzed using ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry. As a result, 134 chemical constituents were identified in seven medicinal herbs, including salvianolic acids, diterpene quinones, phenolic acids, phthalides, cyanogenic glycosides, flavonoids and triterpenoid saponins. Among them, 55 chemical constituents were transferred to DHK along with extraction and preparation, and 26 were further absorbed into blood and metabolized to produce 11 metabolites after oral administration. The transitivity of DHK from medicinal herbs to compound preparation and into blood was analyzed for the first time. This article will be valuable to ascertain the quality markers for quality process control and further pharmacokinetic studies.

中文翻译：

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丹红花榆寇夫叶的质量传递性：超高效液相色谱-四极杆飞行时间质谱对中药，复方制剂和大鼠血浆化学性质的研究。

一种有效的中药制剂丹红花榆寇夫叶（DHK），主要用于治疗因气滞血瘀引起的视力模糊和突然失明，以及视网膜中央静脉阻塞的吸收期。但是，目前的质量标准相对较低，仅规定了原儿茶醛的含量。化学可及性是发现质量标志物的基础，并用于中药的质量过程控制中。在此，使用超高效液相色谱-四极杆飞行时间质谱仪对七种药材，DHK和大鼠血浆的化学成分进行了综合分析。结果，在七种草药中鉴定出134种化学成分，其中包括丹酚酸，二萜醌，酚酸，邻苯二甲酸酯，氰苷，类黄酮和三萜类皂苷。其中，有55种化学成分在提取和制备过程中转移到DHK中，还有26种被口服吸收并代谢为11种代谢产物。首次分析了DHK从草药到复方制剂以及进入血液的传递性。本文对于确定质量标志物以进行质量控制和进一步的药代动力学研究将是有价值的。首次分析了DHK从草药到复方制剂以及进入血液的传递性。本文对于确定质量标志物以进行质量控制和进一步的药代动力学研究将是有价值的。首次分析了DHK从草药到复方制剂以及进入血液的传递性。本文对于确定质量标志物以进行质量控制和进一步的药代动力学研究将是有价值的。