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Debating Eukaryogenesis-Part 1: Does Eukaryogenesis Presuppose Symbiosis Before Uptake?
BioEssays ( IF 3.2 ) Pub Date : 2020-02-20 , DOI: 10.1002/bies.201900157
Dave Speijer 1
Affiliation  

Eukaryotic origins are heavily debated. The author as well as others have proposed that they are inextricably linked with the arrival of a pre-mitochondrion of alphaproteobacterial-like ancestry, in a so-called symbiogenic scenario. The ensuing mutual adaptation of archaeal host and endosymbiont seems to have been a defining influence during the processes leading to the last eukaryotic common ancestor. An unresolved question in this scenario deals with the means by which the bacterium ends up inside. Older hypotheses revolve around the application of known antagonistic interactions, the bacterium being prey or parasite. Here, in reviewing the field, the author argues that such models share flaws, hence making them less likely, and that a "pre-symbiotic stage" would have eased ongoing metabolic integration. Based on this the author will speculate about the nature of the (endo) symbiosis that started eukaryotic evolution-in the context of bacterial entry being a relatively "early" event-and stress the differences between this uptake and subsequent ones. He will also briefly discuss how the mutual adaptation following the merger progressed and how many eukaryotic hallmarks can be understood in light of coadaptation.

中文翻译:

辩论真核生物-第1部分:真核生物是否以共生为先决条件?

真核生物的起源受到了激烈的争论。作者和其他人提出,在所谓的共生环境中,它们与线粒体前α线蛋白细菌样血统的到来密不可分。随后的古细菌宿主和共生共生体之间的相互适应似乎是导致最终真核祖先的过程中的决定性影响。在这种情况下,一个尚未解决的问题涉及细菌最终进入内部的方式。较早的假设是围绕已知拮抗作用的应用,细菌是猎物或寄生虫。在这里,作者在回顾该领域时认为,这些模型存在缺陷,因此使其缺陷可能性降低,并且“共生前阶段”将缓解正在进行的代谢整合。基于此,作者将推测真核生物进化开始的(内生)共生的性质(在细菌进入是一个相对“较早”的事件中),并强调这种吸收与后续吸收之间的差异。他还将简要讨论合并后的相互适应是如何进行的,以及根据共同适应可以理解多少个真核生物标志。
更新日期:2020-03-26
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