PURPOSE The validity and responsiveness of the EQ-5D-3L in visual conditions has been questioned, inspiring development of a vision 'bolt-on' domain (EQ-5D-3L + VIS). Developments in preference-based measures (PBM) also includes the EQ-5D-5L and the ICECAP-O capability wellbeing measure. This study aimed to examine the construct validity and responsiveness of the EQ-5D-3L, EQ-5D-5L, EQ-5D-3L + VIS and ICECAP-O in cataract surgery patients for the first time, to inform choice of PBM for economic evaluation in this population. METHODS The analyses used data from the UK Predict-CAT cataract surgery cohort study. PBMs and the Cat-PROM5 [a validated measure of cataract quality of life (QOL)] were completed before surgery and 4-8 weeks after. Construct validity was assessed using correlations and known-group differences evaluated using regression. Responsiveness was evaluated using effect sizes and analysis of variance to compare change scores between groups, defined by patient-reported and clinical outcomes. RESULTS The sample comprised 1315 patients at baseline. No PBMs were associated with visual acuity and only the ICECAP-O (Spearman's rs =  - 0.35), EQ-5D-3L + VIS (rs =  - 0.42) and EQ-5D-5L (Value Set for England rs =  - 0.31) correlated at least moderately with the Cat-PROM5. Effect sizes of change were consistently largest for the EQ-5D-3L + VIS (range 0.34-0.41), followed by the ICECAP-O (range 0.20-0.34). Results indicated no improvement in responsiveness using the EQ-5D-5L (range 0.13-0.16) compared to the EQ-5D-3L (range 0.17-0.20). CONCLUSIONS Whilst no PBMs comprehensively demonstrated evidence of construct validity and responsiveness in cataract surgery patients, the ICECAP-O was the most responsive generic PBM to improvements in QOL. Surprisingly the EQ-5D-5L was not more responsive than the EQ-5D-3L in this setting.

中文翻译：

---

评估白内障手术患者基于偏爱的措施（PBM）的构建效度和反应性。

用途EQ-5D-3L在视觉条件下的有效性和响应性受到质疑，激发了视觉“螺栓连接”域（EQ-5D-3L + VIS）的发展。基于偏好的度量标准（PBM）的发展还包括EQ-5D-5L和ICECAP-O能力健康度量标准。这项研究旨在首次检查白内障手术患者中EQ-5D-3L，EQ-5D-5L，EQ-5D-3L + VIS和ICECAP-O的构建效度和反应性，为选择PBM提供依据此人群的经济评估。方法该分析使用了来自英国Predict-CAT白内障手术队列研究的数据。PBM和Cat-PROM5 [一种有效的白内障生活质量（QOL）度量标准]在手术前和术后4-8周完成。使用相关性评估构建体有效性，并使用回归评估已知群体差异。使用效应大小和方差分析来评估反应性，以比较各组之间的变化得分，这是由患者报告的和临床结果定义的。结果样本包括基线时的1315名患者。没有PBM与视敏度相关，只有ICECAP-O（Spearman rs =-0.35），EQ-5D-3L + VIS（rs =-0.42）和EQ-5D-5L（England rs =-0.31）与Cat-PROM5至少适度相关。对于EQ-5D-3L + VIS（范围0.34-0.41），其变化效果大小始终是最大的，其次是ICECAP-O（范围0.20-0.34）。结果表明，与EQ-5D-3L（范围0.17-0.20）相比，使用EQ-5D-5L（范围0.13-0.16）的响应性没有改善。结论虽然没有PBM全面证明白内障手术患者的结构有效性和反应性证据，但ICECAP-O是对QOL改善最敏感的通用PBM。令人惊讶的是，在这种情况下，EQ-5D-5L的响应速度并不比EQ-5D-3L更高。