Purpose

The photopic negative response (PhNR) is a negative wave following the b-wave of the photopic electroretinogram (ERG). The PhNR originates from the retinal ganglion cells (RGCs), and it can be used to assess the function of RGCs noninvasively and objectively. The purpose of this study was to determine whether the relative amplitudes (affected/normal eye) of the PhNR are significantly correlated with the degree of the relative afferent pupillary defect (RAPD) in eyes with unilateral or asymmetrical damage of the optic nerve.

Methods

The PhNRs of the full-field photopic ERGs were measured. In addition, videopupillography and automated perimetry were performed on 27 cases with asymmetrical optic nerve disorders including glaucoma. The differences of these assessments were expressed by the relative amplitudes of the PhNRs of the two eyes, the neutral density (ND) filter required to equate the amplitudes of the pupillary light reflexes between the two eyes, and differences of the mean defects (ΔMDs) of the sensitivities of the Humphrey visual fields. The correlations between these values were determined by linear regression analyses.

Results

The relative PhNR amplitudes were significantly and negatively correlated with the ΔMDs (R² = 0.58, P = 0.0001). In addition, the relative PhNR amplitudes were moderately but significantly and positively correlated with the RAPDs (R² = 0.36, P = 0.002).

Conclusion

The relative amplitudes of the PhNR of the affected eyes to the contralateral eyes indicate an asymmetric alteration of the RGCs, and they can be used to monitor the physiology of the RGCs objectively.

中文翻译：

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非对称性视神经疾病的视阴性反应，瞳孔传入缺陷和视野平均缺陷之间存在显着相关性。

目的

视觉负响应（PhNR）是跟在视觉视网膜电图（ERG）的b波之后的负波。PhNR源自视网膜神经节细胞（RGC），可用于无创客观地评估RGC的功能。这项研究的目的是确定PhNR的相对振幅（受影响/正常的眼睛）是否与视神经的单侧或非对称损伤的眼睛的相对传入瞳孔缺损（RAPD）的程度显着相关。

方法

测量了全视野明视ERG的PhNR。此外，对包括青光眼在内的不对称视神经疾病的27例患者进行了影像学和自动视野检查。这些评估的差异表示为两只眼睛的PhNR的相对幅度，等于两只眼睛之间的瞳孔光反射幅度相等的中性密度（ND）滤镜以及平均缺陷（ΔMDs）的差异汉弗莱视野的敏感性。这些值之间的相关性通过线性回归分析确定。

结果

PhNR的相对幅度与ΔMD呈显着负相关（R ²  = 0.58，P  = 0.0001）。此外，相对PhNR振幅与RAPD呈中等但显着正相关（R ²  = 0.36，P  = 0.002）。

结论

患眼与对侧眼的PhNR的相对幅度表明RGC的不对称改变，可用于客观地监测RGC的生理状况。