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Correlating imaging parameters with molecular data: An integrated approach to improve the management of breast cancer patients.
The International Journal of Biological Markers ( IF 2.3 ) Pub Date : 2020-02-20 , DOI: 10.1177/1724600819899665
Mariarosaria Incoronato 1 , Peppino Mirabelli 1 , Anna Maria Grimaldi 1 , Andrea Soricelli 1, 2 , Marco Salvatore 1
Affiliation  

The goal of this review is to provide an overview of the studies aimed at integrating imaging parameters with molecular biomarkers for improving breast cancer patient's diagnosis and prognosis. The use of diagnostic imaging to extract quantitative parameters related to the morphology, metabolism, and functionality of tumors, as well as their correlation with cancer tissue biomarkers is an emerging research topic. Thanks to the development of imaging biobanks and the technological tools required for extraction of imaging parameters including radiomic features, it is possible to integrate imaging markers with genetic data. This new field of study represents the evolution of radiology-pathology correlation from an anatomic-histologic level to a genetic level, which paves new interesting perspectives for breast cancer management.

中文翻译:

将成像参数与分子数据相关联:一种改善乳腺癌患者管理的综合方法。

这篇综述的目的是概述旨在将成像参数与分子生物标志物整合以改善乳腺癌患者的诊断和预后的研究。使用诊断成像来提取与肿瘤的形态,代谢和功能有关的定量参数,以及它们与癌组织生物标志物的相关性是一个新兴的研究主题。得益于成像生物库的发展以及提取包括放射特征在内的成像参数所需的技术工具,可以将成像标记与遗传数据整合在一起。这项新的研究领域代表了放射学-病理学相关性从解剖学-组织学到遗传学水平的演变,这为乳腺癌的治疗提供了新的有趣观点。
更新日期:2020-04-18
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