The presence of hypoxia is a typical feature of solid tumors and has been identified in many neoplasms, favouring the survival of malignant cells in a hostile environment and the expression of an aggressive phenotype. Malignant brain tumors have large proportions of hypoxic tissue, thus contributing to resistance to radiation and chemotherapy. Positron emission tomography (PET) is an attractive technique to gain a non-invasive assessment of tumor hypoxia within the whole tumor, with 18F-fluoromisonidazole (18F-FMISO) and 18F-flouroazomycin arabinoside (18F-FAZA) being the most promising radiotracers. In this short review, we aim to discuss the available clinical studies focused on the use of 18F-FAZA PET/computed tomography in patients affected by high-grade glioma.

中文翻译：

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肿瘤缺氧中的18F-FAZA PET成像：重点研究高级别神经胶质瘤。

低氧的存在是实体瘤的典型特征，并已在许多肿瘤中得到证实，这有利于恶性细胞在敌对环境中的存活和侵袭性表型的表达。恶性脑肿瘤的缺氧组织比例很大，因此有助于抵抗放射线和化学疗法。正电子发射断层扫描（PET）是获得无创评估整个肿瘤内肿瘤缺氧的一种有吸引力的技术，其中18F-氟代咪唑（18F-FMISO）和18F-氟唑霉素阿糖胞苷（18F-FAZA）是最有希望的放射性示踪剂。在这篇简短的综述中，我们旨在讨论可用于临床的临床研究，这些研究集中在受严重神经胶质瘤影响的患者中使用18F-FAZA PET /计算机断层扫描。