Purpose

Platelet microparticles (PMPs), which are microvesicles shed from platelets, participate in inflammation, vascular homeostasis, and thrombosis. PMPs are increased in obese women with polycystic ovary syndrome (PCOS). Agents that modulate hormonal aspects of PCOS could affect the levels of PMPs. The aim of the present study was to evaluate the effects of oral contraceptives (OCPs), antiandrogen, and metformin use for 6 and 12 months on PMPs in normal-weight women with PCOS.

Methods

Forty-five women with PCOS and 13 healthy women were recruited. Biochemical, hormonal, and clinical parameters were recorded. Women with PCOS received treatment with OCPs, OCPs+antiandrogens, or metformin, depending on their main complaint or clinical/biochemical findings. PMPs were measured at baseline and after 6 and 12 months.

Results

At baseline, patients with PCOS had higher levels of PMPs than controls (p = 0.017), which increased after 6-month treatment with OCPs (p = 0.006). Subsequently, they decreased after 12-month treatment (p = 0.046). Metformin had no effect on PMP levels.

Conclusion

In conclusion, PMP levels are increased in PCOS and further increase with OCP use. This effect could possibly contribute to the increased risk of venous thromboembolism associated with OCP use. However, further studies are needed to elucidate the exact role of PMPs in PCOS.

中文翻译：

---

口服避孕药可增加患有多囊卵巢综合征的正常体重女性的血小板微粒水平。

目的

血小板微粒 (PMP) 是从血小板脱落的微泡，参与炎症、血管稳态和血栓形成。患有多囊卵巢综合征 (PCOS) 的肥胖女性的 PMP 增加。调节 PCOS 激素方面的药物可能会影响 PMP 的水平。本研究的目的是评估口服避孕药 (OCP)、抗雄激素和二甲双胍使用 6 个月和 12 个月对患有 PCOS 的正常体重女性 PMP 的影响。

方法

招募了 45 名患有 PCOS 的女性和 13 名健康女性。记录生化、激素和临床参数。患有 PCOS 的女性根据她们的主诉或临床/生化发现接受了 OCP、OCP+抗雄激素或二甲双胍的治疗。在基线和 6 个月和 12 个月后测量 PMP。

结果

在基线时，PCOS 患者的 PMP 水平高于对照组 ( p  = 0.017)，在使用 OCP 治疗 6 个月后增加 ( p  = 0.006)。随后，它们在治疗 12 个月后下降（p  = 0.046）。二甲双胍对 PMP 水平没有影响。

结论

总之，PCOS 患者的 PMP 水平会升高，并且会随着 OCP 的使用而进一步升高。这种效应可能会导致与使用 OCP 相关的静脉血栓栓塞风险增加。然而，需要进一步的研究来阐明 PMP 在 PCOS 中的确切作用。