Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by their strict species and tissue specificity. In this Gem, we discuss the discovery of a murine papillomavirus, Mus musculus papillomavirus 1 (MmuPV1), and how its experimental use represents a major advancement in models of papillomavirus-induced pathogenesis/carcinogenesis, and their transmission.

中文翻译：

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小家鼠乳头瘤病毒 1：乳头瘤病毒发病机制动物模型的新前沿。


病毒发病机制的动物模型是人类疾病研究的重要工具。人乳头瘤病毒（HPV）因其广泛的性传播和致癌潜力而成为一个重大的公共卫生问题。基于感染的乳头瘤病毒发病机制模型因其严格的物种和组织特异性而变得复杂。在这篇 Gem 中，我们讨论了鼠乳头瘤病毒，小家鼠乳头瘤病毒 1 (MmuPV1) 的发现，以及它的实验使用如何代表乳头瘤病毒诱导的发病机制/癌变及其传播模型的重大进展。