The administration of bisphosphonate medications, which target osteoclastic‐bone remodelling, to juvenile and adult racehorses is a matter of debate owing to concerns that these molecules remain bound to the bone‐mineralised matrix and may interfere with subsequent bone growth, adaptation to exercise and healing of bone microdamage in equine athletes. Osteoclasts participate in endochondral ossification, subchondral bone remodelling and bone repair. There is a knowledge gap on the role of equine osteoclast biology in the growth and maturation of joint surfaces and this information is important to inform judicious bisphosphonate use.

中文翻译：

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幼年纯种掌骨软骨下骨中丰富的破骨细胞表明在关节成熟中起重要作用。

由于担心这些分子仍与骨矿化基质结合并可能干扰随后的骨骼生长、对运动的适应和愈合马运动员的骨骼微损伤。破骨细胞参与软骨内骨化、软骨下骨重塑和骨修复。关于马破骨细胞生物学在关节表面的生长和成熟中的作用存在知识空白，这些信息对于明智地使用双膦酸盐很重要。