Lipoxygenases (LOXs) are enzymes which found in organisms that catalyze the peroxidation of polyunsaturated fatty acids (Arachidonic acid, Linoleic acid). The key role of the mentioned enzymes and their metabolites in formation of sensitivities, inflammations, many of cancers (prostate, breast, etc), obesity, diabetes and atherosclerosis had been demonstrated. This review aimed to focus on research findings introducing proved LOXs (5/12/15-LOX) inhibitors, which have been involved in in vivo studies, and discuss on their sources, chemical structures and medicinal applications. By this subject selection, we would introduce the possible LOXs inhibitors (5/12/15-LOX) with special physiological and metabolic levels and open a vision in molecular target selection for the readers.

中文翻译：

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脂氧合酶抑制剂的体内研究概述。

脂氧合酶（LOXs）是在生物体中发现的能催化多不饱和脂肪酸（花生四烯酸，亚油酸）的过氧化的酶。已证明上述酶及其代谢产物在敏感性，炎症，许多癌症（前列腺癌，乳腺癌等），肥胖症，糖尿病和动脉粥样硬化形成中的关键作用。这篇综述的重点是研究成果，介绍已证明的LOX（5/12 / 15-LOX）抑制剂，这些抑制剂已参与体内研究，并讨论了其来源，化学结构和医学应用。通过本主题的选择，我们将介绍具有特殊生理和代谢水平的可能的LOXs抑制剂（5/12 / 15-LOX），并为读者打开分子靶标选择的视野。