The revolution in cystic fibrosis treatment is rooted in tremendous interdisciplinary research efforts, which led in recent years to significant progress in precision medicine. Since 2004, a key annual event for the CF research community is the ECFS Basic Science Conference (BSC), which is an ideal venue for deep discussions around topical subjects and fosters basic CF-related research in Europe and beyond. This special issue explores topics that were featured at the 16th ECFS BSC, held in Dubrovnik in March 2019 and provides an overview of recent progress in various fields for understanding disease mechanisms, developing relevant cell and animal models and designing breakthrough therapies. The special issue also identifies a number of the key issues and challenges in the future development of transformative therapies for all patients with CF.

中文翻译：

---

探索囊性纤维化的基本机制：促进第 16 届 ECFS 基础科学会议的数据展示和讨论

囊性纤维化治疗的革命植根于巨大的跨学科研究努力，这导致近年来精准医学取得重大进展。自 2004 年以来，CF 研究界的一项重要年度活动是 ECFS 基础科学会议 (BSC)，这是围绕主题进行深入讨论并促进欧洲及其他地区的基础 CF 相关研究的理想场所。本期特刊探讨了 2019 年 3 月在杜布罗夫尼克举行的第 16 届 ECFS BSC 上的专题，并概述了各个领域在了解疾病机制、开发相关细胞和动物模型以及设计突破性疗法方面的最新进展。本期特刊还确定了未来所有 CF 患者转化疗法发展中的一些关键问题和挑战。